Product Name: 1,2,3-Trimethylimidazolium Iodide
Chemical Family: Imidazolium salts
CAS Number: 616-47-7
Synonyms: 1,2,3-Trimethyl-1H-imidazol-3-ium iodide
Recommended Use: Laboratory chemicals, intermediate in chemical synthesis, research and development
Supplier: Laboratory chemical suppliers, research chemical vendors
Contact Information: Manufacturer or distributor customer service hotline, emergency phone number for chemical emergencies
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 4; Eye Irritation – Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, harmful in contact with skin, causes serious eye irritation
Pictograms: Exclamation mark (for acute toxicity and eye irritation)
Precautionary Statements: Avoid breathing dust or vapors. Wear eye protection and gloves. Wash thoroughly after handling. Do not eat, drink, or smoke while using the product.
Other Hazards: Possible irritant to skin and respiratory tract. No evidence for carcinogenicity or reproductive toxicity under normal conditions.
Chemical Name: 1,2,3-Trimethylimidazolium Iodide
CAS Number: 616-47-7
EC Number: 210-478-6
Percentage: 98-100% (technical grade)
Impurities: Trace inorganic salts (≤2%) may be present depending on synthesis source
Additives: None intentionally added or required for stability
Inhalation: Move the person to fresh air, keep at rest. Seek medical attention if breathing difficulties develop. Remove source of exposure if safe.
Skin Contact: Remove contaminated clothing and wash skin with large amounts of water and mild soap. Seek medical help if irritation or symptoms persist.
Eye Contact: Immediately flush eyes with plenty of water for 15 minutes, holding eyelids open. Remove contact lenses if present and easy. Get medical attention right away.
Ingestion: Rinse mouth. Get medical attention if feeling unwell; do not induce vomiting unless directed by a physician.
Acute Symptoms and Effects: Irritation of eyes, mucous membranes, skin redness or rash, coughing or difficulty in breathing
Advice for Doctor: Treat symptoms and provide supportive therapy. No specific antidote identified.
Suitable Extinguishing Media: Use water spray, dry chemical powder, CO₂, or foam. Choose extinguisher appropriate for surrounding materials.
Unsuitable Extinguishing Media: Direct water jet can spread chemical or cause splashing.
Specific Hazards: May emit toxic iodine vapors, nitrogen oxides, or methylated imidazole derivatives when heated strongly or burning.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA) and full protective suit. Avoid exposure to gases and smoke produced in fire.
Fire Hazard Behavior: Not classified as highly flammable, but decomposition products can be hazardous under fire conditions. Ensure proper ventilation and prevent runoff into drains.
Personal Precautions: Use gloves, chemical splash goggles, lab coat, and local exhaust ventilation. Do not inhale dust or fumes. Prevent contact with skin and eyes.
Environmental Precautions: Prevent entry into drains, surface waters, and soil. Notify authorities if significant environmental contamination occurs.
Spill Clean-up Methods: Sweep up spilled powder carefully to avoid generating dust. Transfer to a suitable waste container. Clean residue with water and detergent. Dispose of cleanup materials in accordance with local regulations.
Additional Advice: Ventilate area. Avoid spreading dust. Wash hands and exposed skin thoroughly after cleanup.
Precautions for Safe Handling: Use only in well-ventilated locations, preferably fume hood. Avoid inhalation of dust, contact with eyes, skin, and clothing. Do not eat, drink, or smoke during use. Keep away from incompatible materials such as strong oxidizers.
Conditions for Safe Storage: Store in tightly closed containers, away from light, heat, moisture, and sources of ignition. Keep in original container or appropriately labeled inert packaging. Maintain at room temperature or as directed by manufacturer.
Storage Incompatibilities: Separate from oxidizing agents, acids, and ozone-producing devices. Avoid storage with food or personal items.
Other Information: Label storage area clearly. Rotate stock to avoid accumulation of aged material, which could degrade and increase hazard potential.
Occupational Exposure Limits: No community or occupational exposure limits established for this substance. Keep airborne concentrations as low as possible.
Engineering Controls: Local exhaust ventilation, fume hood usage, closed-system operations to reduce dust formation. Provide accessible eyewash stations and safety showers.
Personal Protection: Use chemical-resistant gloves (such as nitrile), laboratory coat, goggles or face shield, and, if dust is present, suitable respirator (such as N95 or P100). Remove contaminated clothing and wash before reuse.
Environmental Controls: Prevent spillage and dust release. Minimize environmental contamination.
Appearance: White to pale yellow crystalline powder
Odor: Faint, slightly musty odor
Odor Threshold: Not determined
pH: 4-6 (1% solution in water)
Melting Point: 180-190°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable
Evaporation Rate: Not applicable (solid)
Flammability: Not flammable under normal conditions
Vapor Pressure: Negligible at 25°C
Vapor Density: Not applicable
Relative Density: 1.60–1.75 (water = 1)
Solubility: Soluble in water, methanol, DMSO
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: >200°C
Viscosity: Not applicable (solid powder)
Chemical Stability: Stable under recommended storage and handling conditions. Avoid exposure to strong heat or sunlight.
Possibility of Hazardous Reactions: Reacts with oxidizing agents to release hazardous products. No polymerization expected.
Conditions to Avoid: Excessive heat, open flames, incompatible substances, moisture
Incompatible Materials: Strong oxidizers, acids, alkali metals
Hazardous Decomposition Products: Iodine vapors, methylimidazole derivatives, nitrogen oxides under fire or decomposition conditions
Other Information: Avoid storage with chemicals that could cause exothermic decomposition.
Routes of Exposure: Inhalation, dermal, ingestion, eye contact
Acute Toxicity: Moderate by oral and dermal exposure (LD50 estimated 300–2,000 mg/kg for rats/mice)
Skin Corrosion/Irritation: May cause irritation, redness, or rash
Eye Damage/Irritation: Risk of serious eye irritation or damage if splashed in eyes
Respiratory Sensitization: May cause irritation of the respiratory tract if inhaled as dust
Carcinogenicity: No listed carcinogenic effects (IARC, NTP, OSHA)
Mutagenicity: Not reported as a mutagen in standard bacterial or animal tests
Reproductive Toxicity: No clear evidence, but exercise caution pending further studies
Chronic Effects: Prolonged or repeated contact may cause localized dermatitis or aggravate pre-existing skin conditions
Other Health Hazards: Individuals with iodine sensitivity may react more strongly to accidental exposure.
Ecotoxicity: Hazardous to aquatic organisms in concentrated form, especially due to iodide content. Avoid discharge into environment.
Persistence and Degradability: Not biodegradable; may persist in soils and aquatic environments.
Bioaccumulation: No significant risk of bioaccumulation expected for parent imidazolium salt.
Mobility in Soil: High water solubility can increase mobility in ground and surface water.
Other Adverse Effects: Avoid uncontrolled release. May alter water chemistry due to ionic nature. Iodide ions can contribute to eutrophication in sensitive environments.
Waste Handling: Dispose as hazardous laboratory waste. Collect in sealed, properly labeled containers.
Waste Disposal Method: Incineration at authorized chemical waste facility. Avoid landfill disposal. Do not release to sewer or water courses.
Contaminated Packaging: Rinse thoroughly with water before recycling or disposal according to local regulations.
Regulatory Compliance: Dispose in accordance with EPA, EC, and local environmental health and safety regulations.
Additional Notes: Professional waste management best ensures safe and responsible disposal of the material.
UN Number: Not assigned for non-bulk consignments; check with carrier if bulk
UN Proper Shipping Name: Not regulated as dangerous goods for land, air, or sea transport, but confirm with local regulations
Transport Hazard Class: Non-hazardous, but handle as a laboratory chemical
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant but prevent spills during transit
Special Precautions: Keep containers tightly closed, upright, and protected from sunlight and moisture. Comply with standard laboratory transport packaging guidelines.
U.S. TSCA: Listed or meets the criteria for listing
EU REACH Status: No registration number assigned; used primarily for research and development purposes only
OSHA Hazard Communicable: Meets criteria as hazardous chemical under OSHA 29 CFR 1910.1200
Canada WHMIS Classification: D2B – Toxic Materials Causing Other Toxic Effects
Other National Regulations: Subject to country and region-specific chemical inventory controls, reporting, and labeling requirements
Other Regulatory Notes: Not subject to specific allowable exposure limits; laboratory and workplace handling must follow chemical hygiene standards. Keep safety documentation available for employee reference according to lab and institutional policies.
