Product Name: 1-Hydroxyethyl-3-Methylimidazolium Acetate
Synonyms: [C2OHmim][OAc], Ionic Liquid
CAS Number: 143314-17-4
Recommended Use: Solvent for cellulose, catalyst in chemical syntheses, materials research
Manufacturer: Company details, emergency contact information, address, phone number, email for technical support, and SDS request
GHS Classification: Eye irritation: Category 2A; Skin irritation: Category 2; Acute toxicity (oral): Category 4
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, harmful if swallowed, may cause respiratory irritation following significant inhalation exposure
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing mists, avoid contact with eyes and skin, wear protective clothing, gloves and face protection as specified by site risk assessments, wash hands thoroughly after handling, do not eat, drink or smoke when using this product
Chemical Identity: 1-Hydroxyethyl-3-Methylimidazolium Acetate
Chemical Formula: C7H12N2O3
Molecular Weight: 172.18 g/mol
Component: 1-Hydroxyethyl-3-Methylimidazolium Cation – 50%; Acetate Anion – 50%
Impurities: Water content <1%, minor by-products from synthesis, no known significant impurities contributing to hazards
Inhalation: Remove person to fresh air, monitor breathing, seek medical attention if symptoms persist or worsen such as cough, headache or dizziness
Skin Contact: Immediately wash skin with plenty of water and mild soap, remove contaminated clothing, seek medical attention for persistent irritation, launder clothing before reuse
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, get medical attention for continued irritation
Ingestion: Spit out material if still present in mouth, rinse mouth with water, do not induce vomiting, seek medical attention
Suitable Extinguishing Media: Use water spray, dry chemical, alcohol foam, or carbon dioxide as appropriate for surrounding fire
Specific Hazards: May release toxic fumes such as nitrogen oxides, carbon monoxide, carbon dioxide, and acetic acid vapors on thermal decomposition
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear for chemical fires
Fire-Fighting Procedures: Cool fire-exposed containers with water spray, prevent run-off from entering drains, stay upwind to avoid inhalation of vapors, evacuate area if large fire occurs
Personal Precautions: Evacuate nonessential personnel, avoid skin and eye contact, ventilate area, wear suitable protective equipment including gloves, goggles and protective clothing
Environmental Precautions: Prevent spill from reaching drains, waterways, and soils, contain spill using non-combustible absorbent material such as vermiculite or sand, use barriers to limit spread
Methods for Cleaning Up: Soak up liquid with absorbent, collect residue and place in a suitable container for disposal, wash the spill site with water and detergent after material removal
Handling: Minimize dust and vapor formation, use only outdoors or in well-ventilated areas, avoid multiple exposures, wash hands after use, ensure equipment is grounded and properly maintained
Storage: Keep container tightly closed, store in a cool, dry, well-ventilated area away from heat, ignition sources, incompatible materials such as strong acids and oxidizers, protect from moisture and direct sunlight
Occupational Exposure Limits: No established exposure limits specific to this product, practice good industrial hygiene
Engineering Controls: Handle in a chemical fume hood or with local exhaust ventilation as needed to control exposure
Personal Protective Equipment: Wear nitrile or neoprene gloves, safety goggles with side-shields, lab coat or chemically resistant apron, use respiratory protection in case of inadequate ventilation or risk of vapor inhalation, safety shower and eye wash stations recommended in work area
Physical State: Liquid
Color: Colorless to pale yellow
Odor: Mild acetate or vinegar-like smell
Melting Point: Below room temperature
Boiling Point: Decomposes before boiling
Flash Point: Greater than 180°C (closed cup, literature estimate)
Solubility: Soluble in water, ethanol, DMSO, and other polar solvents
Vapor Pressure: Very low at room temperature
Density: Approx 1.15–1.20 g/cm³
Viscosity: Viscous liquid at room temperature
pH: Slightly acidic (4-6 in aqueous solution)
Chemical Stability: Stable under normal temperature and storage conditions, hydrolyzes slowly upon prolonged exposure to moisture
Reactivity: May react with strong acids to generate heat and acetic acid vapors, incompatible with strong oxidizing agents, avoid contact with aluminum and zinc
Hazardous Decomposition Products: Thermal decomposition can generate carbon monoxide, carbon dioxide, nitrogen oxides, acetic acid, imidazole derivatives
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat) estimated >2000 mg/kg, can cause headache, nausea or discomfort if ingested in large quantities
Skin Corrosion/Irritation: Causes moderate skin irritation on contact
Serious Eye Damage/Eye Irritation: Causes reversible eye irritation, redness, discomfort
Respiratory Sensitization: Vapor inhalation may irritate respiratory tract, symptoms include cough and sore throat, sensitization not commonly reported
Chronic Toxicity: No data available on repeated dose toxicity, not classified as carcinogen or mutagen by regulatory agencies
Additional Information: Prolonged or repeated exposure can exacerbate symptoms, pre-existing skin or respiratory conditions may increase risk
Ecotoxicity: Data limited for this product, based on chemical structure and related ionic liquids, significant aquatic acute toxicity is not expected at low concentrations
Persistence and Degradability: Partially biodegradable in soil and water, ultimate fate depends on local conditions
Bioaccumulation: Not likely to bioaccumulate due to high water solubility and low log Kow
Mobility in Soil: High mobility expected based on solubility and partition coefficient
Other Adverse Effects: Care should be taken to avoid uncontrolled release to environment, large discharges may affect microbial communities in wastewater treatment
Waste Disposal Methods: Collect product and debris in sealed, labeled containers, conform disposal actions to local, regional and national regulations, avoid release to sewers
Contaminated Packaging: Containers should be triple-rinsed and disposed of in accordance with regulations governing chemical waste, remove labeling prior to re-use or recycling when possible
Special Precautions: Do not landfill large volumes, avoid incineration except in facilities equipped for chemical waste, consult a licensed waste disposal company for large scale disposal
UN Number: Not regulated as hazardous for transport by ground, air or sea under most conditions
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: None
Packing Group: None
Transport Precautions: Protect containers from physical damage, secure loads to prevent shifting, segregate from incompatible materials during transport, transport at ambient temperatures and away from sources of ignition
Labeling Requirements: Complies with OSHA Hazard Communication Standard, GHS labeling for skin/eye irritation and acute toxicity
TSCA Status: Listed or exempt
REACH Registration: May require notification or registration under EU regulations if exported to or produced in European Union
Other Regulations: Product does not appear on any major lists of carcinogens or restricted substances, workplace exposure must align with general chemical hygiene regulations, detailed recordkeeping as per employer and local requirements
Additional Information: Ensure workplace complies with national and regional chemical safety and environmental regulations, safety training for users highly advised
