Product name: 1-Methylimidazole
Chemical formula: C4H6N2
Synonyms: 1-Methyl-1H-imidazole, N-Methylimidazole
CAS number: 616-47-7
Recommended use: Intermediate for pharmaceuticals, solvents, catalysts, corrosion inhibitors
Supplier details: Manufacturer or local agent contact information (include address and telephone number)
Emergency contact: Local toxicology center, supplier emergency line, or regional poison control number
GHS classification: Flammable liquid (Category 3), Acute toxicity (Oral Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal word: Warning
Hazard statements: Flammable liquid and vapor. Harmful if swallowed. Causes skin and eye irritation.
Pictograms: Flame, exclamation mark
Precautionary statements: Avoid breathing vapors, use protective gear, wash hands thoroughly, keep away from ignition sources, use only in well-ventilated areas
Chemical identity: 1-Methylimidazole
Concentration: ≥99% by weight
Impurities: None significant to hazard
Inhalation: Move the exposed person to fresh air, keep comfortable for breathing, seek immediate medical attention if symptoms occur
Skin contact: Remove contaminated clothing, rinse skin with copious water for at least 15 minutes, call a physician if skin irritation persists
Eye contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical advice
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical advice, provide symptom-based supportive care
Most important symptoms: Burning sensation, redness, skin dryness, respiratory tract irritation, nausea, vomiting
Suitable extinguishing media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray (for cooling containers only)
Hazards from combustion: Toxic fumes of nitrogen oxides, carbon oxides
Special protective equipment: Firefighters need chemical splash suits, self-contained breathing apparatus (SCBA)
Advice for firefighters: Evacuate area, use water spray to keep containers cool, avoid water entering sewers or watercourses, extinguish from upwind position
Personal precautions: Evacuate personnel not involved in the clean-up, use appropriate personal protective equipment
Environmental precautions: Prevent material from entering drains or watercourses, inform authorities if spillage contaminates environment
Methods for containment and cleaning: Absorb with dry inert material, transfer to chemical waste container, ventilate area, wash spill area after material pickup, dispose of according to local regulations
Precautions for safe handling: Avoid inhalation and contact with eyes or skin, use chemical fume hood, earth and bond containers to prevent static discharge, do not eat or drink when using product
Conditions for safe storage: Keep in tightly closed container, store in cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizing agents, acids
Specific end uses: See section on recommended use, keep usage in closed systems whenever possible
Control parameters: Workplace exposure limits not established for 1-methylimidazole
Engineering controls: Mechanical exhaust ventilation, enclosed processes, emergency eyewash and shower stations
Personal protection: Safety glasses with side-shields, chemical-resistant gloves (nitrile recommended), lab coat or coveralls, appropriate respiratory protection (nuisance organic vapor cartridge mask or supplied air in confined spaces), avoid direct contact with product
Appearance: Clear, colorless to pale yellow liquid
Odor: Amine-like odor
Odor threshold: Not established
pH: 10-11 (aqueous solution)
Melting point: -60°C
Boiling point: 198°C
Flash point: 81°C (closed cup)
Flammability: Flammable liquid
Vapor pressure: 0.86 hPa at 20°C
Vapor density: >1 (air = 1)
Density: 1.03 g/cm³ at 20°C
Solubility: Miscible with water
Auto-ignition temperature: 445°C
Decomposition temperature: Not specified
Explosive properties: Not considered explosive
Viscosity: Not available
Partition coefficient (log Kow): 0.31
Evaporation rate: Not available
Chemical stability: Stable under standard temperatures and pressures
Reactivity: Reacts with strong oxidizers, acids
Conditions to avoid: Heat, flames, sparks, incompatible substances
Hazardous decomposition products: Nitrogen oxides, carbon oxides under fire or decomposition
Hazardous reactions: Risk of violent reaction with oxidizing chemicals
Routes of exposure: Inhalation, skin and eye contact, ingestion
Acute toxicity: Oral LD50 (rat): 970 mg/kg, Dermal LD50 (rabbit): >2000 mg/kg
Irritation: Causes skin redness and severe eye irritation
Sensitization: No data
Chronic effects: No information on carcinogenic, mutagenic, reproductive, or other chronic effects
Symptoms: Cough, headache, nausea, skin dryness, stinging sensation in eyes
Additional notes: Avoid repeated or prolonged exposure, insufficient evidence for long-term harm
Ecotoxicity: Fish (Oryzias latipes) LC50 (96 h): 410 mg/L, Daphnia magna EC50 (48 h): 202 mg/L, algae EC50 (72 h): >100 mg/L
Persistence and degradability: Expected to biodegrade based on structure, limited detailed data
Bioaccumulative potential: Low (log Kow 0.31)
Mobility in soil: High due to water solubility
Other adverse effects: No data on adverse effects to ozone layer or other long-range environmental impacts
Disposal methods: Collect liquid and solid residues in chemical waste containers, incinerate in permitted facility, reuse or recycle whenever practical
Contaminated packaging: Rinse thoroughly, dispose of as hazardous chemical waste
Special precautions: Follow local, state, and federal regulations, avoid discharge to environment
UN number: UN 2929
Proper shipping name: Toxic liquid, organic, n.o.s. (1-Methylimidazole)
Transport hazard class: 6.1 (Toxic liquids)
Packing group: III
Environmental hazards: Not a marine pollutant
Special precautions: Clearly mark packages, avoid excessive heat during transit, transport with compatible chemicals only
TSCA inventory: Listed
REACH status: Registered or pre-registered in the European Union
OSHA: Regulated as hazardous chemical, SDS required
WHMIS classification (Canada): Class B3 (Combustible liquid), D2B (Toxic material causing other effects)
SARA Title III: Not listed as extremely hazardous, reportable quantity not established
Other regulations: Subject to workplace safety, chemical storage, and environmental regulations by country and locality, provide training and emergency procedures for personnel handling this material
