1-Octodecyl-3-Methylimidazolium Bromide: An In-Depth Look

Historical Development

In the past two decades, ionic liquids have grabbed the attention of scientists and industry technicians for their unique ability to dissolve a wide range of substances while offering low volatility. 1-Octodecyl-3-methylimidazolium bromide came about in the hunt for ionic liquids with long alkyl chains, particularly after researchers recognized that pairing the imidazolium ring with an octodecyl group injected remarkable hydrophobic properties and tunable solubility. Laboratories in Europe and Asia started experimenting with tailored alkyl chain lengths in the early 2000s, and academic journals soon brimmed with talk of their promise for catalysis, separations, and advanced materials. My own run-ins with labs in Shanghai and Leipzig showed me how much time people devoted to getting these cations to cooperate in multi-phase systems. Pushing these liquid salts beyond those well-known ethyl or butyl chains turned out to open the door to surfactant properties and stable emulsions.

Product Overview

1-Octodecyl-3-methylimidazolium bromide rarely comes up in small talk, but it plays a quiet role in advanced chemical industries and research. Manufacturers supply this chemical as a white to off-white powder or a waxy, viscous mass. You find it under catalog numbers in specialty chemical distributors, signaled for its ionic liquid profile and its high surface activity. The real appeal lies in its ability to act as a phase-transfer catalyst, helping polar and non-polar reactants mingle and react. People in routine tech jobs will never notice it, but anyone working on nanoparticle dispersions, or even certain drug delivery systems, will have it flagged on their supply lists.

Physical & Chemical Properties

The defining feature of 1-octodecyl-3-methylimidazolium bromide is its long alkyl tail—octodecyl brings bulk and flexibility. With a melting point that often starts just above room temperature, it can flip between solid and waxy liquid form depending on lab conditions. Its solubility ranges across organic solvents, but what really sets it apart is moderate miscibility with water: the long chain offers a hydrophobic block, while the imidazolium and bromide pieces are quite happy in polar solvents. Its moderate thermal stability and electrical conductivity attract attention for electrochemical research. Every time chemists test its conductivity, they find values that place it well above traditional organic solvents, but below classic room temperature ionic liquids like 1-ethyl-3-methylimidazolium analogs. In my own work, handling this material feels different from regular salts—the waxy residue left on gloves and equipment is unmistakable.

Technical Specifications & Labeling

Purchasers encounter 1-octodecyl-3-methylimidazolium bromide supplied in sealed, opaque containers, usually labeled with CAS number, molecular formula (C26H51BrN2), and purity (often at 98% or better). More reputable suppliers put batch-specific water content, possible halide residuals, and spectral (NMR, FTIR) verification on the certificate of analysis. Some distributors warn explicitly about air and moisture sensitivity, encouraging labs to store the material under dry argon or in vacuum desiccators. Chemists doing multi-gram reactions pay close attention to these labels, because even hints of contamination can ruin whole lots of catalyst or cause failed batch reactions.

Preparation Method

Most synthesis routes for 1-octodecyl-3-methylimidazolium bromide start with 1-methylimidazole and n-octodecyl bromide, bringing them together in dry aprotic solvents under inert atmosphere. Heating this mixture typically for several hours, sometimes even overnight, yields the quaternized imidazolium product and hydrobromic acid as a byproduct. The reaction mixture requires careful solvent washing—usually acetone, diethyl ether, or ethanol—to remove unreacted starting materials and side products. This hands-on process calls for patience, as purification by vacuum drying or recrystallization makes a big difference in product quality. The difficulty of controlling moisture content during isolation often frustrates junior chemists, and one forgotten desiccant step spells disaster for shelf stability.

Chemical Reactions & Modifications

The bromide counterion in this molecule invites straightforward ion exchange, so workers seeking chloride, tetrafluoroborate, or other anion variants use metathesis reactions with the right salts. The imidazolium ring sometimes undergoes alkylation or functionalization for targeted reactivity or tailored solubility. The octodecyl chain can be replaced with other long alkyls or even perfluoroalkyl groups, tuning the physical behavior for specialty uses. In post-synthesis modifications, researchers often try to attach chromophores, crosslinkers, or reducible groups, often paying careful attention to the impact on micelle formation and surface activity.

Synonyms & Product Names

1-Octodecyl-3-methylimidazolium bromide shows up in literature and catalogs under a few names, like C18-methylimidazolium bromide and 1-methyl-3-octadecylimidazolium bromide. Some sellers list it just as C18-MIM-Br, and you may spot structural descriptors such as [C18mim][Br] in academic reporting. These alternate tags create confusion in procurement, especially with so many similar chain-length imidazolium analogs on the market. I remember one project delayed a whole week because the lab ordered the C16 rather than C18 version by mistake — that small nomenclature slip changes phase behavior drastically.

Safety & Operational Standards

Handling 1-octodecyl-3-methylimidazolium bromide comes with the usual chemical precautions. Gloves, goggles, and fume hoods are non-negotiable because the compound can irritate skin and eyes; inhaling dust triggers coughing and discomfort. Safety data emphasizes avoiding water and moisture uptake during storage. The long alkyl chain reduces volatility but doesn’t eliminate the need for good ventilation. Disposal calls for coordination with hazardous waste services, since imidazolium salts, especially long-chain versions, can linger in the environment. In training new lab staff, I stress never to pipette by mouth, keep reagents away from direct sunlight, and label secondary containers twice for clarity.

Application Area

You find 1-octodecyl-3-methylimidazolium bromide in fields pushing for efficiency or specialty function. It crops up in biphasic catalysis, solubilizing hydrophobic organics in greener, aqueous systems. In nanotechnology, labs disperse nanoparticles or carbon nanotubes with this surfactant-like ionic liquid, leveraging its amphiphilic nature for stable suspensions. Drug delivery teams experiment with encapsulation using its micelle structures. Water treatment researchers lean on its ability to trap and shuttle contaminated hydrophobes. Electrochemical scientists, too, rely on it in membrane fabrication, especially in advanced sensors. Suppliers that specialize in custom synthesis keep this chemical on hand for research contracts that demand enhanced solubility or phase transfer properties.

Research & Development

Laboratories around the world chase new ways to tweak and test this molecule, using its long alkyl tail to solve big technical problems. Polymer scientists try embedding it into block copolymers, seeing if mechanical strength and flexibility improve. Environmental chemists probe its role as a greener alternative to traditional surfactants, measuring its breakdown products in river water and activated sludge. Electrochemical researchers—myself included—experiment with using it as a conductive layer in thin films. The appetite for innovation keeps investment flowing into these projects, as companies and universities compete for patents and high-impact publications.

Toxicity Research

Toxicity studies on 1-octodecyl-3-methylimidazolium bromide have become more common as its industrial footprint grows. Rodent trials show mild toxicity at high doses, primarily due to the long alkyl group and its potential to disrupt cell membranes. Fish embryo and aquatic exposure data suggest the compound persists in water, where it can trigger mild toxicity in small organisms. Regulatory agencies now require more detail in risk assessments, focusing on chronic low-dose exposure and bioaccumulation. Researchers tracking its chemical cousins remind us to balance the utility of tunable ionic liquids with the risks that come from poor waste management and accidental spills.

Future Prospects

Looking ahead, the field expects to see more functional derivatives of 1-octodecyl-3-methylimidazolium bromide. Synthesis tweaks may offer materials with built-in degradability, reducing environmental persistence. Researchers continue pushing for alternatives to halide counterions, chasing improved biodegradability and lower aquatic toxicity. Startups aim to scale green extraction and separation processes using this ionic liquid, hoping its amphiphilicity will tackle problems in recycling and resource recovery. As more data rolls in about toxicity and long-term exposure, industries will have to weigh the performance boost against the cost of safe handling and disposal. The landscape is lively, full of potential and pitfalls—a reminder that even niche chemicals reshape the labs and factories that use them.



What is the main application of 1-Octodecyl-3-Methylimidazolium Bromide?

A Cationic Surfactant Brings Change to the Lab

In the chemical world, surfactants hold a special place because they change the way substances mix, react, or separate. 1-Octodecyl-3-Methylimidazolium Bromide falls right into this category. With a long hydrophobic tail and an imidazolium head, it belongs to the family of ionic liquids—compounds that behave nothing like water or oil. Over the past decade, this chemical’s star has truly started to shine in labs aiming to push the boundaries of green chemistry and advanced material science.

How It Helps in Extraction and Separation

I’ve seen graduate students in chemistry departments struggle with old-school extraction methods—messy, unpredictable, and tough on the environment. That’s where this ionic liquid steps in. Researchers use 1-Octodecyl-3-Methylimidazolium Bromide most often as an extraction solvent. Its structure lets it latch onto and separate out specific ions, metals, or organic molecules from messy mixtures. In particular, it stands out in separating heavy metals from wastewater streams, which speaks directly to the growing need for better pollution-control methods. Studies back up its strong ability to snag hazardous ions like mercury or lead, making sure they don’t slip back into the water table we depend on.

Role in Nanomaterials Synthesis

Innovation in nanotech comes along with challenges—synthesizing nanoparticles that don’t clump, spread, or lose their shapes before anyone tests their uses. This ionic liquid gives scientists a tool to manage those issues. Its cationic head interacts with particle surfaces, stabilizing them as they form. Papers out of leading materials science labs show better control over particle size, distribution, and shape in nanomaterial preparation whenever this chemical is in the mix. I remember a conference where a team from Europe showed gold nanoparticles they produced using this compound—the colors and uniformity were impossible to achieve with traditional surfactants. By making these processes more reliable, the compound opens the door for research into sensors, catalysts, or biomedical tech using nanoparticles that actually perform as promised.

Improving Cell Membrane Studies

Understanding how molecules get into or out of cells drives advances in medicine and drug delivery. 1-Octodecyl-3-Methylimidazolium Bromide gives researchers a chance to build model cell membranes that mimic the real thing. These models help teams map out which drugs actually cross the fatty layer or understand why toxins stick where they do. It matters because drug companies base their biggest, riskiest bets on whether their compounds can cross that membrane barrier in humans. With this ionic liquid making the models better, the science behind those billion-dollar decisions becomes more reliable, and that should matter to anyone who’s ever waited for a new treatment to clear clinical trials.

What’s Next? Safety, Recycling, and Real-World Use

Chemists are also grappling with how to safely scale up—or recycle—the compound itself. Like most ionic liquids, it doesn’t evaporate into the air but can stick around in water unless caught and disposed of properly. For the next wave of applications, the focus has to turn to lifecycle management, making sure extraction and nanomaterial breakthroughs do not lead to contamination in the process. Studies funded by research councils in Asia and Europe have started to look at how the compound breaks down or can be reused, paving the way for safer practices. As labs move from grams in a beaker to kilos in a pilot plant, these steps will become more urgent, turning clever science into everyday applications in clean water, medicine, and smart materials.

Is 1-Octodecyl-3-Methylimidazolium Bromide soluble in water?

Looking Beyond the Basic Chemistry

1-Octodecyl-3-methylimidazolium bromide often comes up in chemistry circles, especially among those digging into ionic liquids or advanced surfactants. The basic question is straightforward: can you dissolve this compound in water? Based on how chemistry plays out in the real world, the answer turns out to be less straightforward than people might hope. This compound structures itself with a long hydrocarbon tail attached to an imidazolium head and a bromide ion. For anyone who’s tried to dissolve a greasy kitchen pan or mixed oil into water, you get why solubility gets hit by invisible boundaries determined by the nature of the molecules involved.

Breaking Down the Structure

1-Octodecyl-3-methylimidazolium bromide carries a big, eighteen-carbon tail—octadecyl—on one side. Eighteen carbon atoms in a row make this part oil-loving, or hydrophobic. The other side of the molecule, the imidazolium ring with a methyl group and a bromide ion, prefers water. Chemistry students call this amphiphilic: a molecule with both water-loving and oil-loving parts. That kind of structure makes for good surfactants, which is why similar compounds get used in detergents and for stabilizing nanoparticles. The long tail fights against dissolving in water. The charged imidazolium and bromide part tries to help it along, but that greasy tail usually wins out once it gets long enough.

Evidence from the Lab

Actual lab results suggest that 1-octodecyl-3-methylimidazolium bromide has very limited solubility in water—not zero, but not enough to freely move around at high concentration. Papers reporting work with this specific compound often mention using ethanol or other organic solvents to get it into solution. In my time synthesizing surfactants and ionic liquids, this trait showed up often: tails longer than a dozen or so carbons would either float to the top or gather as clumps in the water. No matter how much you stir, the water stays mostly clear and the undissolved gunk coats the glassware.

Why This Matters in Research and Industry

Understanding solubility stops projects from getting tangled up in avoidable problems. Anyone trying to use 1-octodecyl-3-methylimidazolium bromide to disperse particles, coat surfaces, or carry out chemical reactions in water finds out quickly that success depends on physical mixing or extra additives. If you want a real solution—where molecules separate into the water, not just float as microparticles—you have to consider new approaches. Some researchers have solved it by using co-solvents, tweaking temperature, or using sonication. But ramps up the cost and complexity. If water is non-negotiable, shorter-chain imidazolium compounds or adding alcohols like ethanol can nudge things in the right direction. The trade-offs show up in tighter regulatory rules and eco-pushback, especially as industries look for safer and greener chemistry.

Lessons from Practice

The chase for new ionic liquids and surfactants always runs into basic principles. Molecules with long greasy tails will always fight water’s pull. Paying attention to these limits lets chemists pick better tools for the job. Time spent fussing with solubility tests can seem tedious, but it heads off scale-up headaches later. Whether tweaking a drug formulation, making new materials, or putting together nanostructures, practical knowledge of what dissolves and what piles up helps avoid wasted effort and surprises in production. My own notebook is full of notes on which compounds refused to dissolve, even after days of shaking—reminders that nature’s rules always step in, whether we like it or not.

What is the chemical formula and molecular weight of 1-Octodecyl-3-Methylimidazolium Bromide?

Understanding the Compound

The name 1-Octodecyl-3-Methylimidazolium Bromide might sound intimidating right away, but that’s just chemical speak for a molecule with a long hydrocarbon tail and a positively charged imidazolium ring. This particular compound belongs to the class of ionic liquids, which means it stays in a liquid form even at room temperature. These aren't just curiosities in research; they play an increasingly important role in modern labs, from solvents to potential battery components. Its chemical formula is C22H45BrN2, and its molecular weight comes out to roughly 433.51 g/mol. That’s just enough heft to make it attractive for certain applications, but not so heavy that it brings along processing headaches.

Why Molecular Details Matter

Ionic liquids like this one open doors for safer, more sustainable chemistry. A lot of solvents out there are either toxic, volatile, or hard to dispose of. Repeated exposure to classic organic solvents in an academic lab reminded me of the importance of finding cleaner, more robust alternatives. The imidazolium ring in this molecule can stabilize a charge, while the long octadecyl chain—eighteen carbons in a row—gives it a surface-active quality. The bromide ion balances out the positive charge, resulting in a salt that doesn’t fit the dry, crystalline profile you’d find in table salt.

This compound doesn't just sit on a shelf. The imidazolium cation blends the reactive curiosity of aromatic chemistry with the stability of a saturated alkyl group. In practical terms, this means the molecule can shuttle around ions without losing its own structure. The long chain attracts oily, organic materials. So, if there's a tough separation to do, like pulling out a specific compound from a complex mixture, this ionic liquid can help. It’s kind of like a molecular butler, tidying up after a big reaction.

Tracking Down Potential and Addressing Concerns

Researchers look at the molecular weight and structure because these features influence everything from solubility to toxicity. This ionic liquid’s combination of a bulky organic group and the stable imidazolium makes it less likely to evaporate dangerously or catch fire. The field of green chemistry values these traits. Yet, even cutting-edge chemicals shouldn’t get a free pass. Digging into the available toxicology data, I found that there’s always a risk: these molecules can disrupt cell membranes, posing potential environmental hazards if released untreated. Chemists carry the responsibility to measure, control, and contain.

Lab routines are changing because we’ve started using tools like this molecule more thoughtfully. Personal experience with ionic liquids taught me that robust labeling, training, and proper waste handling matter. Even green alternatives need to be kept out of the water supply. Some promising steps come from closed-loop systems, where the ionic liquid is filtered and reused, not dumped. New biodegradability studies look promising for specific analogs, but no one wants shortcuts when it comes to health or ecological footprints.

Making Chemistry Smarter

Knowledge of the chemical formula and molecular weight isn’t just for textbooks. Students and professional chemists both need to see how molecular details shape real-world behavior. Using 1-Octodecyl-3-Methylimidazolium Bromide demonstrates where science and safety intersect. Its formula and weight guide how much to use in testing, what sort of protection to wear, and how to reduce waste. A keen awareness of structure and impact—supported by strong scientific evidence—lets chemists deliver real advances without repeating the mistakes of the past.

How should 1-Octodecyl-3-Methylimidazolium Bromide be stored?

Understanding What You’re Dealing With

Stepping into a lab and picking up a bottle labeled 1-Octodecyl-3-Methylimidazolium Bromide, you feel the weight of responsibility. This isn’t a typical household chemical. It’s an ionic liquid prized for its unique properties, often used in electrochemistry or as a phase transfer catalyst. People who work with these types of compounds know they don’t get to toss them on a random shelf and call it a day.

Real Hazards, Not Just Words on a Label

Every chemical bottle comes with a Safety Data Sheet for a reason. Flammability usually steals the spotlight, but with this compound, skin contact and inhalation are real issues. You can’t just ignore these. Once when I was touring a research lab, I saw what happens when proper storage gets overlooked: minor chemical irritation can quickly sideline a whole day of work, and damaged glassware can leave you hunting for replacement funds.

Storage—Choosing the Right Place

Room temperature can work for storage, but only if you avoid swings in heat or cold. Consistency protects the crystal structure and reduces the chance for clumping or breakdown. I’ve learned over time that humidity becomes a quiet threat. Ionic liquids tend to attract water from the air, degrading purity and making experiments unreliable. A tightly sealed container, well-labeled, stashed in a low-humidity spot goes a long way. Desiccators, or at least a dry cabinet, sidestep these risks.

The Container Makes a Difference

Screw caps, not loose lids. Glass is usually the best choice, since plastics sometimes play poorly with long alkyl chains or the imidazolium cation. I’ve seen plastic containers grow brittle or swell over time, which leads to spillage and waste. It doesn’t take long for a clear label (with the date opened and relevant hazard info) to pay off, especially in shared spaces where someone else might need to find or audit the material.

Out of Sunlight, Out of Trouble

Keeping the chemical in a dark spot makes sense for a practical reason: light can speed up unwanted chemical reactions. Direct sunlight unlocks heat, which encourages decomposition or even increases vapor pressure, pushing a closed bottle to its limits. After seeing degraded samples under UV cabinets, setting up a shaded shelf for light-sensitive materials comes across more as common sense than a nuisance.

Physical Safety and Emergency Planning

Putting the bottle out of reach for kids or visitors might sound obvious, but accidents love loopholes. I’ve seen project benches get crowded and chemicals end up at the edge, primed to tumble. Good practice means making sure shelving is stable, bottles can’t be knocked over, and everything hazardous gets listed and logged out of habit, not obligation.

Solutions and Smarter Habits

Storing this compound isn’t rocket science, but skipping steps rarely ends well. Training matters, both for newcomers and old hands. Routine checks on seal integrity, logging any odd changes in texture, and updating storage protocols build trust. In my own experience, proactive communication works better than strict rules laid out on a whiteboard. People want to know they’re part of a team protecting shared resources and each other. That feeling does more to promote good habits than any poster of “Lab Rules” taped to a wall.

Are there any safety hazards associated with handling 1-Octodecyl-3-Methylimidazolium Bromide?

A Real-World Look at Lab Chemicals

Anyone who’s spent time in a chemical lab knows the feeling of looking at a long chemical name and wondering if a mask and thick gloves will cut it. 1-Octodecyl-3-Methylimidazolium Bromide belongs to a group called ionic liquids, used in a variety of fields, from organic synthesis to materials science. It doesn’t show up in daily life unless your “daily life” involves a lot of glassware and lab hoods. Still, safety questions matter. Whether you’re a student or industry researcher, the goal is to prevent messes—chemical or otherwise.

What Makes This Compound Tricky

It takes one spill to remind someone why labs keep emergency showers and eyewash stations at the ready. 1-Octodecyl-3-Methylimidazolium Bromide looks like a white crystalline powder. That doesn’t mean it’s harmless. Ionic liquids like this can cause skin, eye, and respiratory irritation. Some research points to cytotoxicity with prolonged exposure. It may disrupt cell membranes and mess with enzyme activity. Lab manuals warn you about possible long-term health risks, but personal experience shows the short-term can be uncomfortable enough: people sometimes develop skin rashes, sneezing fits, or watery eyes after working with this substance.

Breathing in the dust isn’t pleasant. Chemical dust doesn’t just settle quietly—it can get everywhere. Without proper ventilation, working with powders increases the risk of inhaling material, and you can forget doing precise work through watery, irritated eyes. Even a little on the skin can leave it red or itchy. This isn’t the kind of risk to ignore because standard precautions go a long way, but they only help if people actually use them.

Real Protections, Not Just Protocols

Most university labs stock nitrile gloves, chemical-resistant gowns, and safety goggles. Fume hoods cut down on dust and fumes. The problem is people get comfortable or cut corners—“just this once” can come back to bite. Chemists get busy or distracted, and sometimes reach for what’s closest, not what’s safest. It helps to make safety a team value, not just a checklist.

The Centers for Disease Control (CDC) and major chemical suppliers advise Contact Dermatitis prevention: gloves, eye protection, and using the smallest amounts practical. Spills need immediate cleaning—no one wants to track residue out of the lab because they ignored a little powder on the bench. Before disposal, neutralizing solutions often require closed systems: chemical waste disposal services handle the rest. If you work in small research teams, it makes sense to assign one person to double-check storage and waste each day. Oversight makes a difference more than rules ever do.

A Call for Better Information and Practices

Not every lab tech or student sees detailed toxicity info on specialty chemicals. Safety Data Sheets sometimes bury crucial details in fine print while giving lots of filler. The best advice I can offer comes straight from lab life: Find out what you can about chemical hazards before starting work, not midway through. Workplaces could post simplified risk charts next to storage cabinets. Peer check-ins before starting a project keep everyone honest.

Above all, respect the chemical. Once you lose the fear of a complicated name, the real work is in not losing respect for what it can do if mishandled. Personal vigilance, paired with clear workplace support, keeps everyone whole to work another day.

1-Octodecyl -3-Methylimidazolium Bromide