Chemical Name: 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium bromide
Synonyms: Ethyltriphenylphosphonium bromide dioxolane derivative
CAS Number: 119300-68-8
Recommended Use: Laboratory use, research applications, organic synthesis
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Classification: Acute toxicity (oral, dermal, inhalation), eye irritation, skin irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, causes skin irritation
Pictograms: Exclamation mark
Precautionary Statements: Wear protective gloves, clothing, and eye/face protection. Do not eat, drink, or smoke when handling. Wash hands thoroughly after use.
Routes of Exposure: Inhalation, ingestion, skin absorption
Chemical Name: 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium bromide
CAS Number: 119300-68-8
Purity: ≥98%
Impurities: Triphenylphosphine (possible trace impurity), organic solvents (from synthesis), dioxolane derivatives in minor quantities
Molecular Formula: C23H24BrO2P
Molecular Weight: 447.31 g/mol
Inhalation: Move individual to fresh air quickly. Seek medical attention if respiratory distress occurs. Remove from exposure source.
Skin Contact: Remove contaminated clothing. Wash affected area with plenty of water and mild soap. Get medical help if irritation continues.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Hold eyelids apart. Remove contact lenses if present and easy to do. Seek medical evaluation.
Ingestion: Rinse mouth, do not induce vomiting. Drink water to dilute chemical in stomach unless victim is unconscious. Immediate medical advice should be sought.
General Advice: Avoid direct contact; use proper PPE when administering first aid.
Suitable Extinguishing Media: Carbon dioxide (CO2), dry chemical, foam, or water spray for small fires. Larger fires may require water or fog.
Hazardous Combustion Products: Burning releases toxic and irritating gases including carbon monoxide, carbon dioxide, phosphine, bromine compounds.
Special Protective Equipment: Full protective gear, self-contained breathing apparatus for firefighters due to toxic fumes.
Firefighting Procedures: Approach upwind, avoid breathing dust or vapors, and isolate the hazard area. Use water spray to cool exposed containers.
Personal Precautions: Wear gloves, safety goggles, lab coat, and if dust/aerosol is present use a suitable respirator. Avoid breathing vapors, mist, or dust.
Environmental Precautions: Prevent release into drains, watercourses, and soil. Notify local health and environmental authorities if significant spills occur.
Spill Cleanup Methods: Do not touch damaged containers or spilled material without PPE. Use inert absorbent material, collect residue, and place in suitable closed chemical waste container. Ventilate area, wash spill area with plenty of water.
Handling: Use in well-ventilated spaces, preferably inside a chemical fume hood. Avoid contact with skin, eyes, and clothing. Prevent dust and aerosol formation. Do not eat or drink in work area.
Storage: Store in tightly sealed original container in a cool, dry, well-ventilated place away from incompatible materials like oxidizers and strong acids. Keep container upright, separately from food and feed. Label all containers clearly.
Engineering Controls: Work under fume hood. Use local exhaust to minimize exposure. Install emergency eye-wash and safety shower near work area.
Personal Protective Equipment: Chemical splash-resistant goggles, lab gloves (nitrile or rubber), long-sleeve lab coat, closed-toe shoes, NIOSH-approved particulate respirator if dust or aerosols are present.
Hygiene Measures: Wash hands and exposed skin thoroughly before breaks and at end of day. Dispose of contaminated clothing according to chemical safety protocols. Keep work area tidy.
Appearance: White to pale yellow crystalline powder
Odor: Odorless or mild aromatic
Melting Point: Data not widely available; similar compounds: around 180–220°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in polar organic solvents (e.g., acetonitrile, DMSO, methanol), low solubility in water
pH: Not determined (solution dependent upon final solvent)
Flash Point: Not flammable in solid state
Vapor Pressure: Negligible
Partition Coefficient: Data unavailable
Stability: Stable under recommended storage and handling conditions
Chemical Stability: Remains stable in closed containers at normal temperatures and pressures. Should stay away from light and moisture for maximum shelf life.
Incompatible Materials: Strong oxidizers, acids, or bases can trigger hazardous decomposition. Avoid exposure to sources of ignition or extreme heat.
Hazardous Decomposition: Phosphine, bromine-containing fumes, and carbon oxides can develop under fire or decomposition conditions.
Possibility of Hazardous Reactions: No hazardous polymerization expected. Avoid mixing with alkali metals, strong reducing agents, or highly reactive halogen compounds.
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: No comprehensive animal data specific to this compound. Related phosphonium salts may cause harmful side effects if swallowed or absorbed.
Skin/Eye Irritation: Causes irritation, redness, discomfort, tearing or blurred vision after direct contact.
Chronic Exposure: No long-term studies published, though repeated or prolonged exposure can promote dermatitis or respiratory stress.
Sensitization: Not expected for this class, but sensitive individuals may develop allergic response.
Carcinogenicity/Mutagenicity: Not classified as a carcinogen or mutagen as per available literature.
Reproductive Toxicity: No data indicating reproductive harm.
Other Effects: Swallowing can irritate gastrointestinal tract; high doses of phosphonium compounds may interfere with respiratory or neurological processes based on analog data.
Ecotoxicity: Data on environmental fate lacking. Similar organophosphorus salts may display moderate toxicity to aquatic organisms.
Persistence and Degradability: Probably slow biodegradation in soil and water due to stability of phosphonium and bromide.
Bioaccumulation Potential: Unknown, likely low for most phosphonium salts
Mobility in Soil: Limited mobility expected; can bind to soil particles due to ionic nature.
Other Adverse Effects: Runoff could negatively impact water bodies. Prevent large volume release. Compound not expected to harm ozone layer or contribute to global warming.
Waste Treatment Methods: Collect all waste into clearly labeled, leak-proof chemical waste containers for disposal via licenced hazardous waste facility.
Disposal of Product: Follow local, regional, and national regulations. Do not dispose of in household garbage, drains, or natural environments.
Contaminated Packaging: Rinse thoroughly, manage as hazardous material if not fully decontaminated. Remove and destroy all identification labels before disposal.
UN Number: Not assigned specifically; check hazard class of shipment
UN Proper Shipping Name: Organophosphorus compound, n.o.s. (not otherwise specified), if regulated
Transport Hazard Class: Consult transport regulations as classification may differ regionally
Packing Group: III for similar low-risk substances, but specific classification should be verified
Environmental Hazards: May present risk if large quantities discharged during transit
Special Precautions: Double containment, sealed packaging, up-to-date transport documents, secondary containment if in aqueous solutions
Transport Regulations: Comply with domestic and international shipment guidelines including US DOT, IATA, IMDG.
Regulatory Status: Compound not subject to a specific regulatory listing, but individual components (phosphonium, bromide derivatives) may fall under chemical safety and environmental standards.
TSCA Status: Refer to supplier; similar materials typically not listed for broad commercial use without registration
EU Regulation (REACH): Substance not registered; intended for laboratory use only
SARA Title III (USA): Not listed under extremely hazardous substances, but safe chemical management needed
California Proposition 65: Not on Prop 65 list as of 2024
Other Standards: OSHA/WHMIS worker protection applies. Always review site-specific chemical safety codes and local compliance requirements.
