Product Name: 3-Isocyanatopropyltriethoxysilane
Synonyms: Triethoxy(3-isocyanatopropyl)silane
CAS Number: 24801-88-5
Use: Coupling agent, functional additive for coatings, adhesives, sealants
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GHS Classification: Acute Toxicity (oral, dermal, inhalation); Skin Corrosion/Irritation; Eye Damage/Irritation; Respiratory Sensitization; Specific Target Organ Toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled. Causes severe skin burns and eye damage. May cause respiratory irritation, allergic skin reactions, asthmatic symptoms, or breathing difficulties.
Pictograms: Corrosive, Exclamation mark, Health hazard
Precautionary Statements: Avoid all contact with eyes, skin, and clothing. Do not breathe vapors. Use only outdoors or in well-ventilated places. Wear appropriate protective equipment.
Chemical Name: 3-Isocyanatopropyltriethoxysilane
CAS Number: 24801-88-5
Concentration: ≥98%
Impurities: Moisture, < 1%, may aggravate reactivity.
Stabilizers/Additives: Not known
Hazardous Components: Contains isocyanate group, subject to special labeling requirements.
Inhalation: Move to fresh air without delay. Keep airway open. Respiratory distress calls for immediate medical attention. Artificial respiration as needed.
Skin Contact: Remove contaminated clothing. Wash thoroughly with soap and water for at least 15 minutes. Get medical advice for irritation, blistering or burns.
Eye Contact: Rinse immediately with plenty of running water for 15 minutes, lifting eyelids occasionally. Do not allow victim to rub eyes. Immediate medical attention needed.
Ingestion: Rinse mouth. Never induce vomiting unless directed by medical personnel. Seek urgent medical help even for small amounts.
Notes for Doctor: Treat symptomatically. Isocyanate exposure may cause delayed pulmonary edema and sensitization.
Flammability: Combustible liquid and vapor
Extinguishing Media: Use water spray, foam, dry chemical, carbon dioxide
Special Hazards: Toxic and corrosive fumes such as nitrogen oxides, isocyanates, silicon oxides, carbon oxides released during combustion. Vapors heavier than air.
Protective Equipment: Firefighters require self-contained breathing apparatus, full chemical protective suits. Keep away from unprotected individuals.
Other Instructions: Prevent run-off from entering waterways. Cool closed containers with water.
Personal Precautions: Use industry-standard forced ventilation. Remove all sources of ignition. Evacuate non-emergency personnel. Wear chemical-resistant gloves and eye/face protection. Respiratory protection mandatory if exposure risk exists.
Environmental Precautions: Prevent further leakage, spillage, or entry into sewers, basements, or confined areas. Notify authorities for large spills.
Clean-up Methods: Absorb with inert material like dry sand or vermiculite. Transfer to secure, labeled containers for disposal. Residues scrubbed with water and compatible detergent. Decontaminate area.
Handling: Avoid inhalation of vapors, aerosols, or mist. No eating, drinking, or smoking during handling. Ground and bond equipment. Use explosion-proof equipment in areas with vapor risk.
Storage: Keep container tightly closed in a cool, dry, well-ventilated place. Storage temperature preferably below 25°C. Protect from direct sunlight, moisture, and incompatible materials like acids, amines, water.
Special Rules: Store in original container or corrosion-resistant drum. Separate from oxidizers, acids, alcohols, and bases. Label all containers properly.
Occupational Exposure Limits: No specific national exposure limits for 3-Isocyanatopropyltriethoxysilane; control as isocyanate compound.
Engineering Controls: Local exhaust ventilation essential for open handling; provide eyewash stations and showers.
Personal Protection: Chemical-resistant gloves (butyl rubber), goggles or face-shields, impervious clothing, respiratory protection (organic vapor cartridge or supplied air) for significant exposure.
Industrial Hygiene: Wash hands before breaks and after work. No skin contact with contaminated clothing or surfaces. Regular monitoring for airborne isocyanate levels advised.
Appearance: Colorless to pale yellow transparent liquid
Odor: Pungent, acrid
Boiling Point: 250 – 260°C
Melting Point: Not applicable, liquid at room temperature
Flash Point: 108°C
Explosion Limits: Not determined
Vapor Pressure: <0.1 mmHg at 25°C
Density: 1.02 g/cm³ at 20°C
Solubility: Decomposes in water, forms urea derivatives and carbon dioxide
Partition Coefficient: Not available
Auto-ignition Temperature: Not determined
Viscosity: 2-4 mPa·s at 25°C
Chemical Stability: Stable in closed containers under dry, inert atmosphere. Reacts quickly with water, alcohols, and amines producing heat and gaseous by-products.
Reactivity: Violent reaction with moisture, acids, bases. Isocyanate group hydrolyzed by water.
Conditions to Avoid: Moist air, high humidity, elevated temperatures, contamination by incompatible materials.
Incompatible Materials: Water, alcohols, strong oxidizers, acids, amines, bases.
Hazardous Decomposition Products: Carbon oxides, silicon oxides, nitrogen oxides, hydrogen cyanide, isocyanate vapors.
Polymerization: May occur with moisture, heat, or contamination, releasing heat and fumes.
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Harmful by oral, dermal, and inhalation routes (specific LD50 data limited; treat as hazardous isocyanate)
Chronic Effects: Sensitizer for respiratory tract and skin; can cause long-term lung issues such as asthma, bronchitis, or sensitization, even at low exposures.
Corrosive/Irritant Effects: Severe irritant for skin, eyes, respiratory system.
Mutagenicity/Carcinogenicity/Reproductive Toxicity: Not classified based on available data. Extrapolate caution from related isocyanates.
Other Information: No evidence of reproductive hazards; chronic inhalation may increase risk for chronic bronchitis and asthma attacks. Medical conditions such as asthma, eczema, or chronic lung diseases can be triggered or worsened by exposure.
Aquatic Toxicity: No reliable aquatic toxicity data; hydrolyzes rapidly in contact with water.
Persistence and Degradability: Decomposes into insoluble polyurea and siloxane derivatives.
Bioaccumulation Potential: Low, based on rapid hydrolysis and low water solubility.
Mobility in Soil: Limited mobility, prone to bind to soil particles, but reacts to form decomposition products.
Other Adverse Effects: Hydrolysis products may affect aquatic environments by altering pH or forming particulates.
Waste Disposal Methods: Consult local, national, and international regulations. Dispose as hazardous waste via licensed chemical waste handler. Incineration recommended.
Contaminated Packaging: Drain fully and clean before recycling or disposal, never reuse for other materials.
Environmental Precautions: Avoid release to the environment. Prevent entry into watercourses, drains, or soil.
UN Number: 2810
UN Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (contains 3-Isocyanatopropyltriethoxysilane)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Label: Toxic
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Secure upright position, keep away from incompatible materials during transport. Emergency action guides must accompany all shipments.
Chemical Inventory Listing: Listed in major chemical inventories (TSCA, EINECS, DSL, ENCS, etc.) with restrictions in some countries.
Hazard Symbols: Corrosive, Toxic
Labelling Requirements: Contains isocyanate; subject to special labeling in the European Union and certain jurisdictions.
Safety, Health and Environmental Regulations: OSHA, REACH, SARA Title III (Section 313: Isocyanates), California Proposition 65. Users must comply with workplace exposure limits and worker training.
Other Rules: Workplace must follow local chemical handling and waste disposal guidelines, personal protection requirements, and emergency planning regulations.
