Product Name: 4-Bromobutyric Acid
Chemical Formula: C4H7BrO2
Synonyms: 4-Bromobutanoic Acid; Butanoic Acid, 4-bromo-
CAS Number: 2602-30-4
Recommended Use: Chemical intermediate in organic synthesis
Supplier Contact Information: Emergency phone numbers, manufacturer details, and local distributor addresses should be listed clearly for immediate reference during spill or poisoning events.
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Acute toxicity oral (Category 4)
Hazard Statements: Harmful if swallowed; causes skin irritation; causes serious eye irritation.
Pictograms: Exclamation mark
Signal Word: Warning
Precautionary Statements: Avoid breathing dust or fumes; wash skin thoroughly after handling; wear protective gloves, clothing, and eye protection; do not eat, drink, or smoke when using this product.
Potential Health Effects: Inhalation and ingestion may irritate mucous membranes, throat, and gastrointestinal tract. Direct skin or eye contact leads to irritation, redness, or burns in sensitive individuals.
Substance: 4-Bromobutyric Acid
Percentage: ≥ 98% by weight
CAS Number: 2602-30-4
Impurities: Minor traces of related brominated compounds, typically less than 2%.
General Advice: Remove from further exposure and seek medical attention without delay.
Inhalation: Remove to fresh air, keep the person at rest, administer oxygen if breathing is difficult.
Skin Contact: Immediately flush with large amounts of water and mild soap for at least 15 minutes; remove contaminated clothing
Eye Contact: Rinse thoroughly with soft stream of water for 15 minutes, keeping eyelids open.
Ingestion: Rinse mouth, drink a small quantity of water if victim is conscious; do not induce vomiting unless instructed by medical personnel.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Specific Hazards: Thermal decomposition can produce irritating or toxic fumes such as hydrogen bromide, carbon oxides.
Protective Equipment: Full firefighting turnout gear, self-contained breathing apparatus.
Firefighting Instructions: Move containers from danger zone if feasible; prevent runoff from reaching drains or water sources. Contain extinguishing agents from contaminating the environment.
Personal Precautions: Evacuate area, ensure sufficient ventilation, wear protective gear to avoid skin and eye exposure.
Environmental Precautions: Prevent further leakage or spillage if safe to do so; keep material out of sewers and waterways.
Cleanup Methods: Absorb with inert material (sand or vermiculite). Sweep up, place in suitable container for disposal. Wash spill site after material pickup is complete to eliminate chemical residue.
Handling: Use in a chemical fume hood, avoid inhalation of dust or vapors, minimize dust generation. Wash thoroughly after handling. Use tools to avoid direct contact.
Storage: Store tightly closed in a cool, dry, well-ventilated environment away from heat, ignition sources, and moisture. Keep away from strong bases and oxidizing agents. Containers must remain labeled and upright.
Exposure Limits: No specific occupational exposure limits established under OSHA or ACGIH for this substance.
Engineering Controls: Use local exhaust ventilation, process enclosures, or other engineering controls to keep airborne levels below recommended exposure limits.
Personal Protective Equipment: Protective gloves (nitrile, neoprene), safety goggles or face shield, lab coat or apron, and impervious footwear. For spills or large quantities, use full-body chemical protection including respiratory protection (NIOSH-approved respirator).
Appearance: White to slightly off-white crystalline solid
Odor: Slight; faintly unpleasant
Odor Threshold: Not determined
pH: Acidic (solution in water)
Melting Point: 49–53°C (120–127°F)
Boiling Point: 233°C
Flash Point: >100°C
Evaporation Rate: Not established
Flammability: Material is not classified as flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Solubility: Soluble in water, ethanol, organic solvents
Partition Coefficient (log Kow): 1.2 (estimated)
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizing materials
Hazardous Decomposition Products: Bromine, hydrogen bromide gas, carbon monoxide, carbon dioxide on combustion or decomposition
Conditions to Avoid: Excessive heat, exposure to open flames, contact with bases or oxidizing agents
Incompatible Materials: Strong bases, strong oxidizing agents, reducing agents, metals such as sodium or potassium
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 in rats: ~700 mg/kg; likely to irritate mucous membranes upon ingestion; skin and eye irritation in animal studies
Chronic Toxicity: No chronic toxicity studies available; repeat exposure may sensitize or exacerbate dermatitis.
Carcinogenicity: No component present at levels greater than 0.1% is identified as a carcinogen by IARC, NTP, OSHA
Other Effects: Sensitization not established in animal models. Long-term exposure may cause gastrointestinal symptoms or skin defatting.
Ecotoxicity: Limited data available; based on structure, toxic to aquatic life at high concentrations. LC50 values for aquatic species not well established.
Persistence and Degradability: Expected to undergo partial biodegradation in most soils and surface waters over time
Bioaccumulation: Low potential for significant bioaccumulation in aquatic species
Mobility: Moderately mobile in soil. Risks rise if introduced in large volumes to bodies of water.
Environmental Fate: Breakdown products include CO2, water, and bromides, depending on biological activity and sunlight.
Waste Disposal Method: Treat as hazardous waste under local, state, and federal regulations. Incinerate in approved chemical incinerator equipped with afterburner and scrubber. Avoid disposing into drains, natural waterways, or regular municipal waste.
Contaminated Packaging: Rinse and dispose of according to guidelines for hazardous chemical containers. Remove all labels before disposal or reuse.
UN Number: UN 3261
Proper Shipping Name: Corrosive Solid, Acidic, Organic, n.o.s. (4-Bromobutyric Acid)
Transport Hazard Class: 8 (Corrosive material)
Packing Group: III
Marine Pollutant: Not listed as a marine pollutant
Transport Precautions: Keep containers tightly sealed during transport, shield from rough handling and temperature extremes; ensure vehicle drivers are trained and carry emergency response instructions.
TSCA: Listed on the US EPA Toxic Substances Control Act inventory
REACH Status: Registered or pre-registered in the European Union
SARA Title III: Not subject to Section 302, 304, or 313 reporting requirements
California Proposition 65: Not identified as a chemical known to cause cancer or reproductive toxicity
Other Regulations: Comply with all applicable workplace safety, environmental, and transportation laws in each jurisdiction. Review local occupational exposure restrictions and notification requirements for hazardous substances.
