Chemical Name: 4-Bromobutyryl Chloride
Synonyms: 4-Bromobutanoyl Chloride, Butanoyl Chloride, 4-Bromo-
CAS Number: 3344-01-0
Molecular Formula: C4H6BrClO
Molecular Weight: 185.45 g/mol
Recommended Use: Intermediate for organic synthesis, pharmaceuticals, agrochemicals
Manufacturer: Provided by supplier
Supplier Contact: Emergency phone number available on request
Emergency Phone: Sourced from Safety Supervisor or Chemist in charge
GHS Classification: Skin corrosion/irritation (Category 1B), Serious eye damage (Category 1), Acute toxicity oral (Category 4), Acute inhalation toxicity (Category 3), Environmental hazards to aquatic life
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, harmful if swallowed, toxic if inhaled, dangerous to aquatic life with long-term effects
Pictograms: Corrosion, Skull & Crossbones, Exclamation Mark, Environment
Precautionary Statements: Do not breathe dust, fumes, gas, mist, vapors, spray; wash exposed areas thoroughly after handling; avoid release to environment; wear protective gloves, clothing, eye and face protection
Chemical Identity: 4-Bromobutyryl Chloride
Concentration: >98% by weight
Impurities: Minor by-products from synthesis, such as 4-bromobutyric acid, unresolved unreacted starting material
Additives: None known
Inhalation: Move affected person to fresh air right away, provide oxygen if breathing is difficult, seek medical attention urgently
Skin Contact: Remove all contaminated clothing, rinse skin with cool water for at least fifteen minutes, immediately call a poison control center
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and seek medical help
Ingestion: Do not induce vomiting, rinse mouth carefully, give small quantities of water, get medical help immediately
Notes to Physician: Treat as strong acid exposure with brominated organic compound involvement; symptom management for respiratory irritation, burns
Suitable Extinguishing Media: Dry chemical, CO₂ or alcohol-resistant foam; never use direct stream of water
Unsuitable Extinguishing Media: Water jets, since reaction with water can generate corrosive hydrochloric acid vapors
Specific Hazards: Releases toxic fumes of hydrogen chloride, carbon oxides, bromine compounds when burned
Protective Equipment: Self-contained breathing apparatus, chemical-resistant suit, gloves and boots; full protective fire gear in case of large fires
Special Procedures: Approach fire from upwind, dike spill runoff to prevent entry to waterways or sewers, keep containers cool with water spray
Personal Precautions: Evacuate unprotected personnel, ventilate affected area, wear splash-proof goggles, lab coat, gloves, and respirator approved for acid gases
Environmental Precautions: Prevent release to drains, surface water, or soil, contain spill
Methods for Clean-Up: Absorb with dry, inert material such as sand or vermiculite, collect in lidded containers, clean spill site with alkaline detergent
Decontamination: Use sodium bicarbonate or soda ash to neutralize residual material
Precautions for Safe Handling: Use only in chemical fume hood, avoid skin or eye contact, avoid inhalation of vapor or mists, keep away from sources of ignition
Storage Requirements: Store in original, tightly closed containers, cool, dry, and well-ventilated area; segregate from bases, amines, alcohols, water; temperature below 25°C recommended
Incompatible Materials: Water, strong bases, oxidizing agents, alcohols, amines, sodium, potassium
Occupational Exposure Limits: No specific limits in place; use engineering controls
Engineering Controls: Local exhaust ventilation, safety shower, eyewash station
Personal Protective Equipment: Chemical splash goggles, compatible gloves (nitrile, neoprene), full-body apron, NIOSH-approved respirator if exposure likely
Hygiene Measures: Wash hands after handling, before eating, immediately after any chemical contact; do not eat, drink, or smoke in work area
Monitoring Methods: Air monitoring for hydrogen chloride and organic vapors in poorly ventilated areas
Appearance: Clear, colorless to light yellow liquid
Odor: Sharp, acrid, irritating chemical odor
Melting Point: -56°C
Boiling Point: 98-102°C at 12 mmHg
Flash Point: Not determined
Vapor Pressure: 0.9 mmHg at 20°C
Density: 1.55 g/cm³ at 25°C
Solubility: Reacts with water, soluble in organic solvents like chloroform, dichloromethane
pH: Acidic upon contact with water
Partition Coefficient: Log Pow not available
Viscosity: Low viscosity liquid
Chemical Stability: Stable in sealed containers kept dry, unstable in presence of water or moisture
Reactivity: Reacts aggressively with water, alcohols, bases, produces hydrogen chloride vapors and heat
Conditions to Avoid: Humidity, high temperatures, contact with incompatible substances
Hazardous Decomposition: Carbon monoxide, carbon dioxide, hydrogen chloride, bromine, other organics
Polymerization: Does not polymerize on its own, may form hazardous materials with amines or alcohols
Acute Toxicity: Data on laboratory animals point to harmful or fatal effects following ingestion, inhalation, or skin absorption
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Severe burns, difficulty breathing, nausea, cough, convulsions, bluish skin
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, respiratory tract damage; no proven carcinogenicity
LD50/LC50: Data not fully available, comparable acyl halides typically show oral LD50 (rat) between 50-250 mg/kg
Mutagenicity: Not adequately tested, related substances show potential genetic risk
Carcinogenicity: Not listed by IARC, NTP, OSHA
Ecotoxicity: Harmful to aquatic organisms, risk of long-term adverse effects in aquatic environment
Persistence and Degradability: Hydrolyzes rapidly in presence of water, breakdown products harmful
Bioaccumulation: Data lacking, but structurally similar substances may accumulate in aquatic organisms
Mobility in Soil: Low in dry soil, high if spilled with water
Other Adverse Effects: Can release hydrochloric acid and bromine-containing by-products impacting local environments
Disposal Methods: Dispose of by incineration at an approved facility with flue gas scrubbing; small containers should be triple rinsed with compatible solvent then neutralized
Waste Classification: Hazardous waste under local, state and federal regulations
Container Disposal: Decontaminate containers by rinsing, then dispose of with hazardous waste authorities
Precautions: Never discharge to natural water bodies or sewage systems
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (4-Bromobutyryl chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labels: Corrosive
Special Precautions: Keep upright, well-ventilated, away from food, in UN approved containers, document emergency procedures during transport
TSCA: Component listed on US Toxic Substances Control Act inventory
REACH Registration: Not fully registered, check European Union exposure scenario
OSHA: Covered under Hazard Communication Standard, requires labeling and training
SARA Title III: Subject to Sections 311/312 (acute health hazard); not listed under Section 313
Right-to-Know: Listed in select US states (Massachusetts, New Jersey, Pennsylvania)
Other International Listings: Consult local authorities for compliance with country-specific regulations
