Product Name: 4-Carboxybutyltriphenylphosphonium Bromide
Synonyms: CTPB, Phosphonium salt with carboxybutyl group
Product Code: Documented by supplier
CAS Number: 56746-33-5
Recommended Use: Specialty chemical, laboratory research, intermediate in organic synthesis
Supplier: Information provided upon request, detailed on purchase documentation
Contact Number for Emergency: National Poison Control Center, local hazardous materials response
GHS Symbols: Harmful, Irritant
Hazard Class: Eye irritation, Skin irritation, Acute toxicity (oral and dermal exposure possible)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory discomfort
Precautionary Statements: Avoid breathing dust or vapors, wash hands thoroughly after handling, wear gloves and eye protection, keep container tightly closed, use in a well-ventilated area
Potential Health Effects: May trigger allergic or asthmatic responses, irritating to mucous membranes, symptoms include redness, tearing, coughing
Target Organs: Skin, eyes, upper respiratory tract
Chemical Name: 4-Carboxybutyltriphenylphosphonium Bromide
CAS Number: 56746-33-5
Formula: C23H22BrO2P
Concentration: Above 95% (analytical grade)
Impurities: Trace amounts of related phosphonium salts, residual solvents from synthesis below regulatory thresholds
Inhalation: Remove person to fresh air, encourage deep breathing, seek medical attention for persistent coughing or sore throat.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, get medical advice if irritation stays.
Skin Contact: Wash with soap and lots of water, remove contaminated clothing, seek attention if redness or discomfort develops.
Ingestion: Rinse mouth, do not induce vomiting, get urgent medical help, give water to dilute if conscious.
Symptoms: Burning sensation, irritation, nausea, headache
Medical Notes: Symptomatic treatment, no known antidote
Suitable Extinguishing Media: Dry chemical extinguishers, carbon dioxide, foam, use water spray to cool containers
Specific Hazards: Thermal decomposition forms irritating and toxic fumes (hydrogen bromide, phosphorus oxides, carbon oxides), risk increases in enclosed spaces
Protective Equipment: Self-contained breathing apparatus, full body protective gear
Special Procedures: Avoid direct stream of water, try to keep unaffected containers cool with water spray, remove if safe
Combustion Products: Bromide fumes, phenyl-based volatiles, phosphine derivatives under incomplete combustion
Personal Precautions: Use protective gloves, lab coat, safety goggles, avoid dust formation
Environmental Precautions: Prevent entry into drains, sewers, and waterways, contain spills at the source
Cleanup Methods: Scoop up with non-combustible absorbent (vermiculite, sand), place in labeled container for proper disposal, wipe residues with damp cloth
Emergency Procedures: Evacuate immediate area, ventilate room, inform incident response team
Waste Handling: Place cleanup materials in sealed, compatible chemical waste containers
Handling: Minimize dust generation and accumulation, use only in areas with proper ventilation, avoid inhalation and repeated skin contact, don’t eat or drink near chemicals
Storage: Keep in tightly closed containers, store in a cool, dry, well-ventilated space away from strong oxidizing or reducing agents
Incompatibilities: Strong acids, bases, oxidizers, halide sources
Recommended Storage Temp: Room temperature or as labeled by supplier
Special Packaging: Prefer sealed glass bottles lined in secondary containment, labeled by hazard class
Engineering Controls: Local exhaust ventilation, chemical fume hood for weighing or mixing, safety shower and eyewash near use area
Exposure Limits: No official workplace exposure limits set, minimize exposure as low as sensible
Personal Protective Equipment: Nitrile gloves, safety goggles, lab apron, capable face mask in poorly ventilated areas
Hygiene Practices: Wash hands and face before breaks and after handling, keep work clothes separate from street wear
Monitoring Procedures: Routinely inspect air quality in confined spaces
Appearance: White to off-white crystalline powder
Odor: Odorless or faint sweet chemical scent
Molecular Weight: 445.3 g/mol
pH: Not available (weak base in solution)
Melting Point: Around 210°C (decomposes)
Solubility: Soluble in water, methanol, DMSO; scorches in strong acids
Boiling Point: Not applicable (decomposes well before boiling)
Vapor Pressure: Negligible at room temperature
Density: Close to 1.4 g/cm³ (estimated)
Partition Coefficient: Not tested
Other Properties: Stable under normal conditions, forms toxic vapors at high temperatures
Chemical Stability: Stable under recommended handling and storage conditions
Conditions to Avoid: Excessive heat, open flames, prolonged direct sunlight, contact with moisture
Materials to Avoid: Strong acids, alkalis, oxidizers
Hazardous Decomposition: Hydrogen bromide, phosphorus oxides, aromatic hydrocarbons
Polymerization: Doesn’t polymerize under ambient or storage conditions, avoid contamination
Reactivity: Not highly reactive with most materials, release of fumes possible if heated greatly
Acute Toxicity: Limited direct data, estimated LD50 (oral, rat) above 500 mg/kg
Irritation: Causes irritation to eyes, skin, respiratory tract, can cause redness, tearing, itchiness
Sensitization: Not fully studied, care taken due to related phosphonium salts’ records
Chronic Effects: No adequate data on repeated exposure toxicity; use basic precautions to prevent build-up
Specific Target Organ Toxicity: Not confirmed in controlled studies
Mutagenicity/Carcinogenicity: No evidence in animal studies, not classified as mutagenic or carcinogenic by major agencies
Reproductive Toxicity: No known reports, avoid exposure for pregnant workers
Aquatic Toxicity: Not measured in complete bioassays, suspected moderate toxicity due to bromide content and aromatic groups
Persistence and Degradability: Slow biodegradation, persistent in aquatic environments
Bioaccumulative Potential: Thought to be low, but real-world data not available
Mobility in Soil: Compound likely binds to organic matter, may leach through loose, sandy soils
Ecotoxicity Effects: Bromide ions can affect aquatic organisms at high levels, risk increases with runoff
Other Hazards: Avoid uncontrolled release to waterways—institutional protocols recommended
Waste Treatment: Collect in sealed, chemically compatible containers; never dump untreated material to environment
Disposal Methods: Hand over to licensed hazardous waste disposal contractor, incinerate in a controlled facility if local laws allow
Contaminated Packaging: Rinse empty containers with water; treat rinses as chemical waste, puncture or break glass before landfill where allowed
Disposal Precautions: Avoid dust, wear protection through all decontamination steps, document manifest and waste code as per hazardous waste requirements
UN Number: Not regulated for most forms of ground transport, keep separate from food and feed
Proper Shipping Name: Chemicals, n.o.s. (contains 4-Carboxybutyltriphenylphosphonium Bromide)
Hazard Class: Not assigned, treat as harmful/irritant, package to minimize breakage
Packing Group: Not assigned, use Group III equivalent robust containers
Labels: Irritant, keep dry, avoid inhalation graphics as appropriate
Special Transport Precautions: Keep away from heat sources, prevent spills or mechanical shocks, carry documentation of hazard and all emergency measures
Inventory Listings: Not listed as restricted by TSCA, EINECS, or major chemical regulatory bodies to date
Hazard Codes: China WGK: 2, no R or S phrases officially assigned
OSHA Status: Not classified as hazardous under US OSHA standards but take laboratory precautions
SARA Title III Status: Not subject to specific SARA requirements
California Proposition 65: Not on list as of current update
Other Information: User required to comply with local chemical safety laws, institutional rules for handling synthetic intermediates
