Product Name: Ethyl 4-Chlorobutanoate
Chemical Formula: C6H11ClO2
Synonyms: Butanoic acid, 4-chloro-, ethyl ester
CAS Number: 623-06-1
Recommended Use: Intermediate in organic synthesis, laboratory reagent
Manufacturer: Refer to purchase label for updated supplier contact
Address: Refer to bottle or purchase documents
Emergency Phone Number: Refer to packaging for specific contact
Classification: Flammable liquids (Category 3); Acute toxicity, Oral (Category 4); Skin irritation (Category 2); Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Keep away from heat, sparks, open flames; wear protective gloves, eye protection; wash hands thoroughly after handling; avoid breathing vapors; use only outdoors or in a well-ventilated area.
Potential Health Effects: Inhalation can trigger headaches, dizziness, or respiratory irritation. Skin absorption can cause redness or local irritation. Eye exposure may lead to persistent discomfort and watering.
Chemical Name: Ethyl 4-Chlorobutanoate
Concentration: >98%
Impurities or Stabilizers: No significant secondary components expected in standard grade. Trace impurities can exist but pose minimal hazard compared to main compound.
Inhalation: Remove exposed person to fresh air immediately. Seek medical attention if symptoms like coughing, dizziness, or shortness of breath persist.
Skin Contact: Wash thoroughly with soap and water. Take off contaminated clothing. Seek advice if rash or irritation develops.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses, keep eyelids open, and continue rinsing. Medical evaluation advised if stinging remains.
Ingestion: Rinse mouth, avoid inducing vomiting. Offer water in small sips and seek immediate medical help. Bring product label to emergency personnel.
Suitable Extinguishing Media: Use carbon dioxide, alcohol foam, or dry chemical agents. Water can help cool containers but will not fight solvent flames directly.
Unsuitable Extinguishing Media: Direct water jet can spread the burning liquid.
Specific Hazards: Vapors can form explosive mixtures with air. Combustion may produce toxic gases, including hydrogen chloride and carbon monoxide.
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective clothing. Approach from upwind to avoid vapor exposure.
Firefighting Instructions: Move unaffected containers out of danger zone if safe. Cool with water spray. Keep evacuation routes clear.
Personal Precautions: Evacuate non-essential personnel. Wear chemical-resistant gloves, splash-proof goggles, and a laboratory coat. Use a respirator in enclosed areas.
Environmental Precautions: Prevent product from entering drains or surface waters. Use absorbent barriers.
Spill Response: Cover spill with inert absorbent (sand, soil, vermiculite). Gather residue into secure, labelled containers. Provide ventilation.
Clean-Up Procedures: Wash area with large amounts of water after removal of material. Collect contaminated cleaning water for disposal.
Handling: Strictly avoid inhaling vapors or contacting skin and eyes. Handle in fresh-air conditions or under fume hood. Keep containers closed when not in use. Label transfer vessels.
Storage Conditions: Store in tightly sealed original packaging. Location must be cool, dry, away from ignition sources. Separate from oxidizing agents.
Incompatible Materials: Strong oxidizers, strong bases, amines.
Special Precautions: Ground and bond all transfer equipment. Never reuse empty containers without cleaning.
Engineering Controls: Operate in fume hood or ensure effective local ventilation.
Respiratory Protection: Use organic vapor respirator when exposed above limits or in poorly ventilated zones.
Skin Protection: Laboratory nitrile or neoprene gloves; impervious apron.
Eye Protection: Safety glasses with side-shields or goggles.
Occupational Exposure Limits: No established threshold value. Minimize vapor presence to lowest practical.
Hygiene Measures: Remove contaminated clothing on site. Don’t eat, drink, or smoke while handling.
Appearance: Colorless to pale yellow liquid
Odor: Ester-like fruity scent
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: -43°C
Boiling Point/Range: 200-202°C at atmospheric pressure
Flash Point: 87°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Upper/Lower Flammable Limits: Not defined; vapors heavier than air
Vapor Pressure: 0.41 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.09 g/mL at 20°C
Solubility: Insoluble in water; soluble in alcohols, ethers
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 330°C
Decomposition Temperature: Above 200°C
Viscosity: Not determined
Chemical Stability: Stable under normal lighting and temperature in closed containers.
Reactivity: Reacts with oxidizing agents and strong bases.
Conditions to Avoid: Heat, flames, sparks, long-term sunlight.
Hazardous Decomposition Products: Releases toxic fumes like hydrogen chloride, carbon monoxide, carbon dioxide.
Polymerization: Not reported under typical storage and use.
Acute Toxicity: Oral LD50 (rat): estimated around 400 mg/kg
Skin Corrosion/Irritation: Can produce redness, dryness, or blistering after repeated or prolonged contact.
Serious Eye Damage/Irritation: Irritating to eyes, causes excessive watering and burning.
Respiratory or Skin Sensitization: No data confirming sensitization reported, but potential exists with chronic exposure.
Germ Cell Mutagenicity: Not classified for mutagenicity.
Carcinogenicity: Not recognized as a carcinogen by IARC, NTP, or OSHA.
Reproductive Toxicity: No definitive data.
Potential Routes of Exposure: Inhalation, skin contact, eye contact, accidental ingestion.
Symptoms: Coughing, sore throat, skin rash, abdominal pain, nausea.
Toxicity: Harmful to aquatic life in concentrated spills; limited information on long-term effects.
Persistence and Degradability: Expected to degrade slowly under typical environmental conditions.
Bioaccumulative Potential: Limited evidence of significant bioaccumulation.
Mobility in Soil: Moderate mobility; can leach to groundwater if released.
Other Adverse Effects: Not expected to significantly impact air or soil at laboratory usage levels.
Waste Treatment Methods: Incinerate in a facility with adequate flue gas cleaning or dispose of in accordance with federal, state, and local regulations.
Contaminated Containers: Rinse thoroughly, triple rinse if required, and deliver to an approved chemical waste disposal contractor.
Disposal Prohibitions: Never dispose of undiluted product down household or laboratory drains.
Disposal Advice: Consult your local environmental safety officer for site-specific protocols.
UN Number: UN 3272
UN Proper Shipping Name: Esters, n.o.s. (Ethyl 4-chlorobutanoate)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Environmental Hazards: Considered Marine Pollutant in bulk quantities
Special Precautions: Use only properly labeled, chemically resistant containers during transport. Protect from physical damage and keep upright.
OSHA: Regulated as hazardous chemical
TSCA: Listed on the United States Toxic Substances Control Act Inventory
SARA Title III: Does not meet threshold reporting quantities.
California Proposition 65: Not listed
EU REACH: Substance is registered or exempted as appropriate.
Other Regulatory Info: Check regional guidelines for additional local requirements on labeling, handling, air emissions, and waste.
