Product name: Hexamethonium Bromide
Chemical formula: C12H30Br2N2
CAS number: 80-51-3
Synonyms: Methonium bromide, hexamethylenebis(trimethylammonium) bromide
Recommended use: Laboratory reagent, academic research
Supplier: Refer to local distributor details on packaging
Emergency contact number: Refer to local regulatory requirement or poison control center
Classification: Acute oral toxicity Category 3, Skin irritation Category 2, Eye irritation Category 2, Specific Target Organ Toxicity (single exposure) Category 3
Signal word: Danger
Hazard statements: Toxic if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary statements: Avoid breathing dust, wash thoroughly after handling, do not eat or drink while using, use protective equipment for eyes and skin
Potential health effects: Inhalation may cause irritation or toxic effects, ingestion can bring abdominal pain, convulsions or respiratory depression, skin and eyes may develop inflammatory reactions after exposure
Chemical identity: Hexamethonium Bromide
Concentration: 98-100%
Impurities: Any known impurities are to be listed on the certificate of analysis, generally present in trace quantities
Molecular weight: 370.21 g/mol
Structural formula: Refer to chemical structure shown on safety datasheet
Eye contact: Rinse cautiously with water for several minutes, remove contact lenses if easy, continue rinsing and seek medical attention
Skin contact: Remove contaminated clothes, wash affected skin with plenty of water and soap, seek immediate medical help for persistent irritation
Inhalation: Move the person to fresh air, provide oxygen if available and breathing difficulty persists, seek prompt medical advice
Ingestion: Rinse mouth, do not induce vomiting, call poison control and obtain medical attention without delay
Most important symptoms: Trouble breathing, abdominal distress, visual disturbances, muscle weakness
Suitable extinguishing media: Water spray, dry chemical, foam, or carbon dioxide
Fire hazards: On combustion, releases toxic and corrosive fumes such as hydrogen bromide, nitrogen oxides, and carbon oxides
Protective equipment: Firefighters use self-contained breathing apparatus and full protective clothing
Special procedures: Avoid inhalation of fumes, cool containers with water spray if safe
Explosion risk: Not sensitive to mechanical impact or static discharge
Personal precautions: Use suitable respiratory protection, chemical resistant gloves, splash goggles, and avoid generating dust
Spill clean-up methods: Avoid dispersal of dust, sweep or vacuum up material, place in sealable labeled container for chemical waste
Environmental precautions: Prevent spill from entering water courses or sewage systems
Methods for containment: Dampen spillage to avoid dust generation, ventilate the area
Handling precautions: Use in well-ventilated space, avoid inhalation and contact with skin and eyes, use protective equipment including gloves and goggles, ensure containers are tightly closed
Storage conditions: Store in original container, tightly sealed, in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids
Incompatibilities: Keep away from oxidizing agents and acids, avoid exposure to excess moisture
Hygiene measures: Wash hands after handling, keep work area clean, avoid eating, drinking, or smoking in workplace
Engineering controls: Work in chemical fume hood or ensure adequate local exhaust ventilation, use equipment resistant to corrosive agents
Personal protective equipment: Wear chemical-resistant gloves (nitrile or neoprene), splash-proof goggles, lab coat, and appropriate respiratory protection if exposure limits may be exceeded
Occupational exposure limits: No established limits by OSHA, NIOSH, or ACGIH, minimize exposure by using safe work practices
Environmental exposure controls: Prevent substance from entering drains or watercourses
Appearance: White crystalline powder
Odor: Odorless
Odor threshold: Not applicable
pH (1% solution in water): Slightly basic around pH 8-9
Melting point/freezing point: Approximately 228°C (decomposes)
Boiling point/range: Decomposes before boiling
Flash point: Not applicable (non-flammable solid)
Evaporation rate: Not available
Flammability: Non-flammable
Vapor pressure: Negligible
Relative density: About 1.35–1.40 g/cm³
Solubility: Soluble in water, slightly soluble in alcohol
Partition coefficient (log Kow): Not determined
Auto-ignition temperature: Not determined
Chemical stability: Stable under normal conditions, avoid moisture and heat
Hazardous reactions: Not reactive under recommended conditions, violent reaction may occur with strong oxidizers
Decomposition products: At high temperatures forms toxic fumes including hydrogen bromide, nitrogen oxides, and carbon oxides
Conditions to avoid: Excess humidity, high temperature, sources of ignition
Incompatible materials: Strong oxidizing agents and mineral acids
Acute toxicity: Oral LD50 (rat): Approximately 75 mg/kg
Routes of exposure: Eyes, skin, inhalation, ingestion
Symptoms of exposure: Gastrointestinal upset, respiratory depression, visual impairment, low blood pressure, muscle weakness, paralysis in overdose
Skin corrosion/irritation: May cause irritation and redness
Serious eye damage: May cause severe irritation, tearing, redness, blurred vision
Respiratory effects: Cough, shortness of breath, chest tightness if dust inhaled
Chronic effects: No data found for chronic toxicity, minimize repeated exposure
Carcinogenicity: Not classified as carcinogen by OSHA, IARC, or NTP
Ecotoxicity: Toxic to aquatic organisms, high water solubility increases risk of adverse environmental impact in case of spillage
Persistence and degradability: Not rapidly biodegradable, persists in the environment
Bioaccumulation potential: Low, but material highly soluble in water
Mobility in soil: Expected to have high mobility due to solubility
Water hazard class: 2 (hazardous for water, Germany)
Other adverse effects: Avoid release to the environment, spills require immediate containment
Waste treatment methods: Dispose of as hazardous chemical waste, consult local regulations for incineration or disposal in chemical landfill
Contaminated packaging: Dispose of containers as hazardous waste following thorough cleaning
Additional precautions: Do not dispose with regular household or municipal waste, follow all federal, state, and local regulations
UN number: 2811
UN proper shipping name: Toxic solid, organic, n.o.s. (Hexamethonium Bromide)
Transport hazard class: 6.1 (Toxic substances)
Packing group: II
Marine pollutant: Yes
Special precautions for user: Use compatible containers, ensure correct labeling, transport in accordance with national laws
US TSCA: Listed
European EINECS/ELINCS: 201-284-0
Canada DSL/NDSL: Check status with supplier
Regulatory labeling: Required in accordance with local hazard communication standards
Workplace controls: Employers provide training and information as required by OSHA Hazard Communication Standard and similar rules in other countries
