Product Name: Methyl 3-Bromopropanoate
Synonyms: 3-Bromopropionic acid methyl ester, Propanoic acid, 3-bromo-, methyl ester
CAS Number: 5445-17-0
Molecular Formula: C4H7BrO2
Molecular Weight: 167.00 g/mol
Recommended Use: Organic synthesis, chemical research
Manufacturer/Supplier: Laboratory chemical supplier or chemical company
Contact Information: Emergency phone number, address of supplier
GHS Classification: Acute toxicity (Oral: Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing vapors; wash thoroughly after handling; do not eat, drink or smoke when using this product; wear protective gloves, clothing, and eye protection; if you feel unwell, get medical attention
Routes of Entry: Inhalation, ingestion, skin, and eye contact
Target Organs: Skin, eyes, respiratory tract, gastrointestinal tract
Chemical Name: Methyl 3-Bromopropanoate
CAS Number: 5445-17-0
Concentration: ≥ 98%
Impurities: None expected at significant levels for lab-grade material
Hazardous Components: No additional hazardous components anticipated beyond main ingredient
Inhalation: Move to fresh air; provide oxygen if breathing becomes difficult; seek medical attention for symptoms
Skin Contact: Take off contaminated clothing; wash skin gently with plenty of water and soap; get medical help for persistent irritation
Eye Contact: Rinse with plenty of water for at least 15 minutes; lift eyelids occasionally and remove contact lenses; consult an eye doctor
Ingestion: Rinse mouth with water; do not force vomiting; call poison control or a doctor immediately
Most Important Symptoms: Redness, irritation, nausea, coughing, discomfort in respiratory tract, abdominal pain
Advice for Rescuers: Use protective gear to prevent self-exposure
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct water jet
Special Hazards: Fire may release hazardous vapors such as hydrogen bromide, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective suit
Fire-Fighting Procedures: Approach from upwind, keep containers cool with water spray, avoid inhaling fumes
Personal Precautions: Use appropriate personal protective equipment, avoid creating dust or mist, ventilate area
Environmental Precautions: Prevent entry to sewers, surface water, or soil
Clean-Up Methods: Absorb with inert material like sand or vermiculite, collect in suitable closed containers for disposal
Decontamination: Clean affected area with soap and water after removal of material
Spill Reporting: Inform safety officer, comply with local regulations on chemical spills
Safe Handling: Only use in well-ventilated areas, do not breathe vapors, avoid skin and eye contact, keep container tightly sealed
Storage Conditions: Store in a cool, dry, well-ventilated place, away from incompatible chemicals, protect from light and moisture
Incompatibles: Strong oxidizers, strong bases, strong acids
Storage Container Materials: Keep in original containers made of chemically compatible materials
Other Precautions: Make sure all containers are properly labeled; open containers with caution in fume hood
Engineering Controls: Use chemical fume hood; provide eyewash stations, safety showers
Respiratory Protection: Use NIOSH-approved respirator if exposure limits are exceeded
Skin Protection: Chemical-resistant gloves (nitrile or neoprene), lab coat, apron
Eye Protection: Safety goggles with side shields, face shield for large-scale work
Hygiene Measures: Do not eat, drink, or smoke in working area; wash hands before breaks and after handling
Exposure Limits: No established ACGIH or OSHA exposure limits for this compound as of latest update
Appearance: Clear to pale yellow liquid
Odor: Slightly pungent, ester-like
Odor Threshold: Not determined
pH: Not applicable
Melting Point: -17°C
Boiling Point: 176-179°C
Flash Point: 71°C (closed cup)
Evaporation Rate: Not established
Flammability: Combustible liquid
Upper / Lower Flammability Limits: Not determined
Vapor Pressure: 2.1 mmHg (20°C)
Vapor Density: 5.8 (air = 1)
Relative Density: 1.478 g/cm³ (20°C)
Solubility: Slightly soluble in water; soluble in organic solvents
Partition Coefficient (log Kow): 0.57 (calculated)
Autoignition Temperature: Not determined
Decomposition Temperature: May decompose on heating
Viscosity: Not measured
Explosive Properties: Not explosive under normal conditions
Stability: Stable under recommended conditions, but decomposes if exposed to heat and light
Reactivity: No dangerous reactions known during normal use
Conditions to Avoid: Elevated temperature, exposure to moisture and sunlight
Incompatible Materials: Strong acids, strong bases, oxidizers, reducing agents
Hazardous Decomposition: Carbon monoxide, carbon dioxide, hydrogen bromide
Polymerization: Not expected under standard handling
Acute Toxicity: Oral LD50 (rat): 640 mg/kg
Inhalation: May cause respiratory tract irritation, coughing, shortness of breath
Skin Corrosion/Irritation: Causes irritation, redness, local discomfort
Serious Eye Damage/Irritation: Causes irritation, watering, redness
Chronic Effects: No data on long-term effects from repeated exposure
Sensitization: Not anticipated to cause allergic response from current data
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No information available
Reproductive Toxicity: No information available
Additional Health Information: Symptoms from high exposure can include headache, drowsiness, nausea
Ecotoxicity: Data scarce, may be harmful to aquatic organisms through acute exposure
Persistence and Degradability: Expected to be biodegradable due to ester functionality
Bioaccumulative Potential: Low, based on calculated log Kow
Mobility in Soil: Likely to have moderate mobility; spilled material could reach groundwater
Other Effects: No evidence of significant environmental persistence or widespread hazard
Avoid Release: Take steps to prevent release to the environment during use or disposal
Waste Disposal Methods: Incinerate in a chemical incinerator with afterburner and scrubber, according to local, regional, and national regulations
Contaminated Packaging: Dispose of as unused product, follow same controls for handling and containment
Recycling: No established protocols for recycling
Precautions: Handle waste in closed containers with proper labeling
Regulatory Compliance: Adhere to hazardous waste disposal guidelines in your location
UN Number: Not assigned for this compound
Shipping Name: Not regulated as a hazardous material by DOT or IATA for small quantities
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Transport in tightly sealed, clearly labeled containers; avoid rough handling or breakage
TSCA Status: Listed
REACH Status: Not registered; laboratory reagent in exempt quantities
SARA Title III: Not listed for specific thresholds
California Proposition 65: Not listed
Canadian WHMIS: D2B (skin/eye irritant, based on chemical similarity)
Other Regulations: Comply with workplace safety laws, chemical hygiene plans, and institutional requirements
