Product Name: Methyl 4-Bromobutyrate
CAS Number: 6224-07-1
Synonyms: 4-Bromobutyric acid methyl ester
Recommended Use: Laboratory chemical, chemical synthesis
Manufacturer/Supplier: Chemical suppliers, research distributors
Emergency Telephone: See supplier's details for country-specific line
GHS Classification: Acute toxicity (oral), Category 4; Skin irritation, Category 2; Eye irritation, Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Pictograms: Exclamation Mark
Precautionary Statements: Avoid contact with skin and eyes. Do not eat, drink, or smoke while using this product. Wear protective gloves and eye protection.
Routes of Exposure: Inhalation, ingestion, skin, and eyes
Chemical Identity: Methyl 4-Bromobutyrate
CAS Number: 6224-07-1
Purity: ≥98%
Impurities: Trace quantities of unreacted butyric acid derivatives or solvents (proprietary)
Molecular Formula: C5H9BrO2
Molecular Weight: 181.03 g/mol
Inhalation: Move to fresh air and keep at rest. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash skin with plenty of soap and water for at least 15 minutes. Seek medical advice for persistent irritation.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present and easy to do. Continue rinsing. Obtain medical attention if irritation continues.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by a medical professional. Seek immediate medical care.
Symptoms and Effects: Irritation, redness, abdominal pain, nausea, headache, drowsiness if overexposed.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam. Avoid direct water jets as they may spread fire.
Specific Hazards: Releases toxic gases such as hydrogen bromide, carbon monoxide, and carbon dioxide on combustion.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear. Approach fire from upwind, keep containers cool with water spray.
Fire Behavior: Liquid can form flammable mixtures with air above its flashpoint.
Personal Precautions: Wear suitable protective equipment including gloves, goggles, and respirator. Evacuate area; ventilate contaminated zone.
Environmental Precautions: Prevent entry into sewers, waterways, or soil. Contain spill using inert absorbent materials such as sand or vermiculite.
Methods for Cleaning Up: Collect liquid into labeled containers for disposal. Absorb remainder with inert material. Wash spill site after material pickup.
Reference to Other Sections: Refer to handling, disposal, and personal protection guidance.
Handling: Work in a well-ventilated area, preferably in a chemical fume hood. Minimize exposure by wearing protective gloves and eyewear. Keep away from sources of ignition and incompatible substances.
Storage: Store tightly closed in a cool, dry, and well-ventilated place. Keep container upright and secure to prevent leaks. Protect from moisture, heat, and sunlight. Store separately from strong bases, oxidizers, and acids.
Hygiene Practices: Wash hands after handling. Do not store or consume food and beverages near this substance.
Occupational Exposure Limits: No specific exposure limit set for this material. Use general chemical safety practices to minimize exposure.
Engineering Controls: Use fume hood or local exhaust. Eyewash station and safety shower should be easily accessible.
Personal Protective Equipment:
Gloves: Nitrile or neoprene recommended
Eye Protection: Chemical splash goggles
Skin Protection: Lab coat or apron
Respiratory Protection: NIOSH-certified respirator, if ventilation is inadequate or during large-scale use
Appearance: Colorless to pale yellow liquid
Odor: Mild ester-like
Odor Threshold: Not determined
pH: Not applicable
Melting Point/Freezing Point: Below -20 °C
Boiling Point/Range: 194–197 °C
Flash Point: 85 °C
Evaporation Rate: Not determined
Flammability: Combustible liquid
Vapor Pressure: 0.76 mmHg at 25 °C
Vapor Density: Not determined
Relative Density: 1.407 at 25 °C
Solubility in Water: Slightly soluble
Partition Coefficient (n-octanol/water): Not available
Autoignition Temperature: Not available
Decomposition Temperature: Not known
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts with strong oxidizing agents, reducing agents, and strong bases.
Hazardous Decomposition: Formation of hazardous gases like hydrogen bromide, methyl bromide, and carbon oxides on thermal decomposition.
Conditions to Avoid: Moisture, heat, sources of ignition, incompatible materials.
Polymerization: Not expected under normal conditions.
Acute Toxicity: Harmful if swallowed. May cause moderate toxicity via oral route (LD50: >300 mg/kg in rats estimation).
Skin Corrosion/Irritation: Causes irritation; prolonged contact may result in burns.
Serious Eye Damage/Irritation: Causes serious eye irritation; may result in pain or redness.
Respiratory Sensitization: No data available, not expected to sensitize airways.
Carcinogenicity: Not listed by NTP, IARC, or OSHA.
Mutagenicity: No genetic toxicity expected based on chemical structure.
Reproductive Toxicity: Not established.
Target Organ Effects: May affect central nervous system with overexposure.
Ecotoxicity: May be harmful to aquatic organisms, with potential to cause long-term effects in aquatic environments.
Persistence and Degradability: Not readily biodegradable. May persist in soil and water.
Bioaccumulation Potential: Not established; low to moderate based on structure.
Mobility in Soil: May leach into groundwater if released into environment.
Other Adverse Effects: Avoid direct release to the environment. Follow regional environmental regulations and industry best practices.
Disposal Methods: Dispose of residue and contaminated materials via certified chemical waste contractor. Do not discharge to drains, surface water, or soil.
Container Disposal: Rinse thoroughly and dispose in accordance with local, national, and regional regulations. Do not reuse empty packaging.
Additional Notes: Seek guidance from applicable waste management authorities for proper handling and disposal.
UN Number: Not regulated for transport under most international transport regulations; check with carrier.
Proper Shipping Name: Methyl 4-Bromobutyrate
Hazard Class: Non-hazardous for ground and air transport under normal quantities.
Packing Group: Not classified
Marine Pollutant: Not specifically listed as marine pollutant
Special Transport Precautions: Secure containers during shipment. Avoid extreme temperatures and physical damage.
US TSCA: Listed
DSL/NDSL (Canada): Listed or meets criteria
EINECS/ELINCS: Listed: 228-302-1
OSHA Hazards: Irritant
SARA 313: Not subject
California Prop 65: Not listed
Other Regulations: Workers handling this chemical must receive safety training. All containers require appropriate hazard labelling.
