Product Name: Methyl 4-Chlorobutyrate
Synonyms: 4-Chlorobutyric acid methyl ester, 4-Chlorobutyric acid methyl ester
Chemical Formula: C5H9ClO2
Molecular Weight: 136.58 g/mol
CAS Number: 3153-37-5
Recommended Use: Intermediate for organic synthesis, research chemical
Supplier Details: Manufacturer and distributor information provided on SDS document
Emergency Contact: CHEMTREC phone numbers available in full documentation
GHS Classification: Skin Irritant (Category 2), Eye Irritant (Category 2A), Specific target organ toxicity (Category 3)
Pictograms: Exclamation Mark
Signal Word: Warning
Hazard Statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust or vapors. Wash hands thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves, clothing, and eye protection.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Signs and Symptoms: Redness, itching, swelling, watery eyes, irritation of respiratory tract
Chemical Name: Methyl 4-Chlorobutyrate
CAS Number: 3153-37-5
Concentration: 98-100%
Impurities: None reported at hazardous levels
Mixtures: Not applicable, product is a single substance
Other Ingredients: No additives or stabilizers specified
Inhalation: Move affected person to fresh air, keep at rest, seek medical advice for persistent symptoms.
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water, wash thoroughly with soap and water, seek medical attention if irritation develops.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, get medical help if irritation persists.
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention.
Most Important Symptoms: Burning, pain, redness, respiratory discomfort, gastrointestinal upset
Note to Physician: Treat symptomatically; consider observation for delayed effects
Suitable Extinguishing Media: Dry chemical, CO2, water spray, alcohol-resistant foam
Unsuitable Media: High volumes of water may spread contamination
Hazardous Combustion Products: Hydrogen chloride, carbon monoxide, carbon dioxide, phosgene
Protective Equipment: Firefighters need to wear self-contained breathing apparatus and protective clothing
Specific Hazards: Containers can explode if heated, combustion may release toxic gases
Advice for Firefighters: Cool exposed containers with water spray, avoid inhaling smoke or fumes
Personal Precautions: Evacuate area, use appropriate personal protective equipment including gloves, safety goggles, and suitable respirator
Environmental Precautions: Prevent spillage from entering drains, ground, or water sources
Spill Cleanup Methods: Absorb liquid with sand, earth, or suitable inert absorbent, collect into suitable container for disposal
Decontamination: Clean spill area with soap and water after material has been collected
Ventilation: Increase ventilation in affected area to disperse vapors or fumes
Handling: Use only in well-ventilated areas, avoid inhalation or contact with skin and eyes, handle with chemical-resistant gloves and safety glasses, prevent static discharge by grounding
Storage: Store in tightly closed, clearly labeled containers, keep in cool, dry, well-ventilated place away from heat, open flames, incompatible substances such as strong acids, bases, and oxidizers
Special Precautions: Keep out of reach of children and unauthorized personnel, do not eat, drink, or smoke in storage or handling areas
Occupational Exposure Limits: No specific limits for Methyl 4-Chlorobutyrate found in OSHA, NIOSH, or ACGIH databases
Engineering Controls: Local exhaust ventilation, eye wash stations, safety showers
Personal Protective Equipment: Appropriate chemical-resistant gloves (such as nitrile), safety goggles or face shield, lab coat or apron, use NIOSH/MSHA-approved respirator if airborne exposure is possible
Hygiene Measures: Wash hands and face before breaks and after handling, remove contaminated clothing, launder before reuse
Appearance: Colorless to pale yellow liquid
Odor: Slight, ester-like
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: -38°C
Boiling Point: 193-195°C
Flash Point: 81°C (closed cup)
Evaporation Rate: Not determined
Flammability: Not highly flammable, may form combustible mixtures at elevated temperatures
Vapor Pressure: 1.2 mmHg at 20°C
Vapor Density: Heavier than air
Relative Density: 1.12 g/cm³ at 20°C
Solubility: Slightly soluble in water, miscible with many organic solvents
Partition Coefficient (n-octanol/water): 1.1–1.2
Autoignition Temperature: Not available
Decomposition Temperature: Not specified
Viscosity: Not determined
Chemical Stability: Stable under normal conditions of storage and use
Reactivity: Not highly reactive but reacts with strong oxidizing agents, strong bases
Possibility of Hazardous Reactions: May react exothermically with incompatible materials
Conditions to Avoid: Heat, sparks, open flame, moisture, static discharge
Incompatible Materials: Strong acids, alkalis, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, phosgene
Acute Toxicity: LD50 (oral, rat): not clearly established but considered to have moderate toxicity
Skin Corrosion/Irritation: Causes skin irritation based on animal data and structural analogues
Serious Eye Damage/Irritation: Can cause eye irritation, redness, tearing
Respiratory or Skin Sensitization: Not classified as sensitizer
Mutagenicity/Genotoxicity: Limited data available, not classified
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No data indicating reproductive effects in humans
STOT-Single Exposure: May cause respiratory system irritation
Chronic Toxicity: Prolonged exposure may cause dermatitis or respiratory discomfort
Symptoms of Exposure: Burning sensation, coughing, sore throat, redness, discomfort
Toxicity (Aquatic): Harmful to aquatic life, limited data suggests moderate acute toxicity to fish and algae
Persistence and Degradability: Expected to be biodegradable based on ester structure
Bioaccumulative Potential: Bioconcentration factor estimated to be low to moderate
Mobility in Soil: Moderately mobile, some risk of leaching to groundwater
Other Adverse Effects: Avoid release to environment, not considered persistent organic pollutant
Waste Disposal Methods: Dispose of as hazardous waste according to local, state, and federal regulations
Contaminated Packaging: Rinse and dispose of containers as hazardous waste
Method of Treatment: Incineration in appropriate facility, chemical disposal must comply with environmental regulations
Precautions: Avoid release to sewers, soil, water systems
UN Number: Not regulated in small quantities under most shipping regulations
Proper Shipping Name: Methyl 4-chlorobutyrate
Transport Hazard Class: Not classified as dangerous for transport (check local and international requirements)
Packing Group: Not applicable
Labeling Requirements: Not required unless shipped in bulk or under specific jurisdictions
Environmental Hazards: Not marine pollutant
Special Precautions for Transport: Keep upright and tightly closed, avoid physical damage
TSCA: Listed on US Toxic Substances Control Act Inventory
REACH: Pre-registered/registered in Europe
SARA Title III: Not listed on hazardous chemical lists
California Proposition 65: Not listed
DSL/NDSL (Canada): Listed/Not listed
WHMIS Classification: Not a controlled product
Other Regulatory Requirements: Must be handled by qualified personnel in compliance with chemical hygiene and environmental laws
