Product Name: Methyltriphenylphosphonium Bromide
Chemical Formula: C19H18BrP
CAS Number: 1779-49-3
Synonyms: MTPB, Bromotriphenylphosphoniummethyl, Methyltriphenylphosphonium bromide
Manufacturers: Specialty chemical suppliers and academic/research chemical vendors
Recommended Use: Used in organic synthesis, particularly as a Wittig reagent; laboratory research and development
Contact Information: Available from chemical suppliers; refer to vendor label for emergency phone and address
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 3, Eye Irritation Category 2A
Pictogram: Exclamation mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes mild skin irritation; Causes serious eye irritation
Precautionary Statements: Avoid breathing dust/fume/gas/mist/vapors/spray; Wash skin thoroughly after handling; If in eyes: Rinse cautiously with water for several minutes; Remove contact lenses, if present and easy to do
Potential Health Effects: Significant irritant to skin, eyes, and mucous membranes; may be harmful if ingested
Environmental Hazards: Potential aquatic toxicity; care must be taken to prevent runoff into drains
Chemical Name: Methyltriphenylphosphonium Bromide
Common Name: MTPB
Concentration: >99% (typical for laboratory-grade material)
CAS Number: 1779-49-3
Molecular Formula: C19H18BrP
Impurities: Product expected to contain only trace manufacturing byproducts, such as triphenylphosphine oxide (<0.5%)
Inhalation: Move affected person to fresh air; seek medical attention if symptoms persist (such as dizziness, coughing, or irritation)
Skin Contact: Remove contaminated clothing, rinse skin gently with plenty of soap and water; seek medical attention if irritation or reaction develops
Eye Contact: Rinse immediately with clean water for at least 15 minutes, lifting eyelids; seek prompt medical attention
Ingestion: Rinse mouth; give water if conscious but do not induce vomiting unless directed by a medical professional; seek immediate medical help
Symptoms: Burning eyes, skin irritation, stomach discomfort, respiratory irritation
Medical Attention: Comprehensive evaluation needed if exposure is significant or involves mucous membranes
Suitable Extinguishing Media: Use dry chemical, CO2, alcohol-resistant foam, or water spray as appropriate for surroundings; avoid straight water jets
Specific Hazards: During combustion, material releases toxic fumes such as carbon monoxide, carbon dioxide, hydrogen bromide, and oxides of phosphorus
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective clothing
Thermal Decomposition: Promotes hazardous smoke; containers may burst in fire if heated
Special Precautions: Avoid breathing vapors; contain runoff to minimize environmental impact
Personal Precautions: Evacuate unnecessary personnel; wear full protective gear including gloves and safety goggles
Spill Response: Avoid generating dust; sweep up material with non-sparking tools and place in a segregated, labeled container for disposal
Environmental Precautions: Prevent entry into watercourses, drains, or soil; use absorbents to contain any runoff
Cleaning Methods: Ventilate area; wash residues from spill area with detergent and water
Waste Handling: Dispose of orbents and cleaning materials as hazardous chemical waste
Handling: Work in a well-ventilated area, minimizes dust exposure, avoid inhalation and skin contact, do not eat/drink/smoke in work area
Protection: Wear suitable lab coat, gloves, chemical-resistant goggles; remove contaminated clothing promptly
Safe Storage: Store in tightly closed containers, in a dry, cool, well-ventilated area away from incompatible materials such as strong oxidizers and acids
Segregation: Keep separate from food, feedstuffs, and incompatible reagents
Transfer: Use clean, inert tools and containers; prevent spillage and secondary contamination
Occupational Exposure Limits: No established limits for this compound; use good laboratory practices
Engineering Controls: Employ chemical fume hoods or local exhaust ventilation to minimize airborne dust
Personal Protection: Use NIOSH-approved respirator if dust is generated; safety goggles; nitrile gloves; lab coat
Hygiene Practices: Wash hands after contact; avoid touching face during handling; change contaminated clothes immediately
Environmental Exposure Controls: Prevent discharge to environment; use catch trays and secondary containment where appropriate
Appearance: White to off-white crystalline solid or powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Neutral to slightly basic aqueous solutions
Melting Point: 282 – 285°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable under expected conditions
Evaporation Rate: Not applicable (solid material)
Flammability: Not classified as flammable
Vapor Pressure: Negligible at ambient temperature
Vapor Density: Not applicable
Solubility: Slightly soluble in water, more soluble in polar organic solvents (ethanol, DMSO, acetonitrile)
Partition Coefficient (n-octanol/water): Data unavailable
Density: Approximately 1.4 - 1.6 g/cm³ at 25°C
Decomposition Temperature: Decomposes at elevated temperature, releasing toxic gases
Viscosity: Not applicable (solid)
Chemical Stability: Stable under standard conditions if stored properly
Reactivity: Reacts with strong oxidizing agents, acids; forms hazardous decomposition products
Conditions to Avoid: Exposure to moisture, direct sunlight, elevated temperatures
Incompatible Materials: Strong oxidizers, acids, halogenating reagents, bases
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, phosphorus oxides, phenyl derivatives
Polymerization: Does not undergo hazardous polymerization
Routes of Exposure: Skin and eye contact, inhalation of dust, ingestion
Acute Toxicity: LD50 (oral, rat): estimated 200-2000 mg/kg (category 4, harmful if swallowed)
Skin Irritation: Can cause redness, itching, or mild dermal irritation
Eye Damage: Expected to cause irritation, redness, possible conjunctivitis
Respiratory Effects: May cause coughing, throat irritation with excessive dust
Sensitization: Not data to suggest sensitization risk
Chronic Effects: Repeated exposure may result in dermatitis
Carcinogenicity: No information indicating carcinogenic potential
Mutagenicity: No mutagenic effects observed in standard laboratory screening
Reproductive Toxicity: No data suggesting reproductive risk available
Ecotoxicity: Limited data; potentially hazardous to aquatic life with longer-term effects
Mobility: Non-volatile, limited solubility in water reduces mobility in soil
Persistence: Degrades slowly under environmental conditions; not expected to bioaccumulate
Bioaccumulation: Low potential due to low partition in lipids
Aquatic Toxicity: Expected to be hazardous to small aquatic organisms if discharged in quantity
Degradability: May persist in water and soils; breakdown may require advanced oxidation processes
Ozone Depletion Potential: Not considered hazardous to the ozone layer
Disposal Methods: As hazardous waste, follow local, regional, national, and international regulations
Product Disposal: Dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with afterburner and scrubber
Contaminated Packaging: Decontaminate containers where practical; dispose of via licensed waste disposal contractor
Environmental Priorities: Prevent release into environment, avoid runoff to soil, surface water, or drains
UN Number: Not assigned for this substance
DOT (US): Not regulated
IMDG: Not classified as dangerous for transport by IMDG code
IATA: Not regulated
Packing Group: Not applicable
Special Precautions: Avoid accidental release; ship in robust primary and secondary containers
OSHA: Not specifically listed as hazardous substance but handle under general laboratory safety guidelines
TSCA Inventory: Listed
REACH Status: Not registered under REACH (use restricted to research and development)
SARA Title III Sections 302, 304, 313: Not established
WHMIS (Canada): D2B (Toxic Material Causing Other Toxic Effects)
RoHS: Not applicable
Other Regulations: Refer to regional standards; laboratory chemical hygiene plans apply; record-keeping and labeling requirements enforced by institutional biosafety rules
