Product Name: Tert-Butyl 4-Bromobutyrate
CAS Number: 22205-74-5
Synonyms: tert-Butyl 4-bromobutanoate, 4-Bromobutyric acid tert-butyl ester
Recommended Use: Chemical intermediate for synthesis, research and development
Manufacturer: Chemical manufacturer contact details on shipping documents
Emergency Contact: Local emergency services or national poison center
Product Code: Assigned by distributor
Prepared by: Health and Safety Department, technical division
GHS Classification: Skin Irritation, Category 2; Eye Irritation, Category 2; Acute Toxicity (oral), Category 4
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Wash skin thoroughly after handling, wear eye protection and gloves, avoid inhalation, do not eat, drink, or smoke during use, rinse mouth if ingested
Routes of Entry: Skin, eyes, ingestion, inhalation
Potential Health Effects: Burning or redness on contact, possible digestive discomfort, irritation of respiratory tract if inhaled
Chemical Name: Tert-Butyl 4-Bromobutyrate
Concentration: >98%
Impurities: Minimal, proprietary process-related traces possible
Molecular Formula: C8H15BrO2
Molecular Weight: 223.11 g/mol
Other Identifiers: EINECS 244-807-9
Inhalation: Move person to fresh air, stay with person, seek medical attention for symptoms
Skin Contact: Rinse area thoroughly with water and soap, remove contaminated clothing, use emergency shower for large spills
Eye Contact: Rinse cautiously with water for at least 15 minutes, hold eyelids apart, remove contact lenses if present, get medical care
Ingestion: Rinse mouth, do not induce vomiting, provide water if conscious, call poison control or physician
Note for Medical Responders: Treat symptomatically, consider potential for chemical-induced respiratory distress, monitor patient for delayed effects
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical, water spray
Unsuitable Media: Direct stream of water may spread substance
Specific Hazards: Emits toxic fumes including carbon oxides and hydrogen bromide under fire conditions
Protective Equipment: Full protective gear with self-contained breathing apparatus
Firefighting Instructions: Avoid run-off entering drains or water bodies, contain and collect fire-fighting water
Explosion Hazards: Vapors can form explosive mixtures with air under certain conditions
Personal Precautions: Put on gloves, safety goggles, laboratory coat, avoid direct contact
Environmental Precautions: Avoid release to sewers, soil or waterways
Cleanup Methods: Absorb spill with sand or vermiculite, scoop up with non-sparking tools, place material in closed chemical waste container
Decontamination: Wash spill site after cleanup, ventilate area
Emergency Procedures: Evacuate unprotected persons, restrict access to area until cleanup is complete
Handling: Work in fume hood or well-ventilated area, prevent prolonged skin and eye contact, avoid breathing vapors, use only with adequate ventilation, do not mix with incompatible substances
Storage Conditions: Keep container tightly closed in cool, dry, well-ventilated place, away from heat sources, moisture, and incompatible materials
Incompatible Materials: Strong oxidizing agents, strong acids, alkali metals
Other Precautions: Label containers clearly, limit access to trained staff, regularly assess storage areas for leaks or damage
Engineering Controls: Use local exhaust ventilation, laboratory fume hood for transfers and handling
Exposure Limits: No OSHA, ACGIH or NIOSH limits specifically established for this substance; treat as low-to-moderate hazard based on structure and function
Personal Protection: Nitrile gloves, chemical splash goggles, flame-resistant laboratory coat
Respiratory Protection: Use appropriate mask or respirator when ventilation is insufficient
Hygiene Measures: Wash hands after handling, before breaks and eating, remove contaminated clothing before leaving work area
Appearance: Colorless to pale yellow liquid
Odor: Mild ester or fruity
Odor Threshold: Not established
Melting Point: -30 to -20 °C
Boiling Point: 90-92 °C at 10 mmHg
Flash Point: >85 °C (closed cup, estimate)
Autoignition Temperature: Not available
Solubility: Insoluble in water, miscible with organic solvents
Vapor Pressure: <5 mmHg (20 °C)
Vapor Density: No definitive information
Density: 1.19-1.23 g/cm³ (20 °C)
pH: Not applicable
Partition Coefficient (n-octanol/water): Not determined
Evaporation Rate: Not established
Viscosity: No significant data
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: Reacts with strong oxidizers and strong bases
Decomposition Products: Carbon oxides, hydrogen bromide, other unidentified substances in fire
Conditions to Avoid: Heat, flames, sparks, direct sunlight, moisture
Polymerization: Not likely under normal handling
Sensitivity to Static Discharge: Not established
Acute Toxicity: Limited human exposure data; animal studies point to moderate toxicity by ingestion
Skin Corrosion/Irritation: Can induce redness and irritation with direct contact
Eye Damage/Irritation: May cause eye redness, discomfort, temporary visual effects
Sensitization: No data on respiratory or dermal sensitization, consider as possible based on structure
Carcinogenicity: Not classified by IARC, NTP or OSHA
Mutagenicity: No reports suggesting mutagenic potential
Reproductive Effects: Insufficient information from published data
Chronic Toxicity: Prolonged or repeated contact may cause dermatitis or respiratory issues
Target Organ Effects: Not established in humans
Ecotoxicity: No measured data for aquatic or terrestrial toxicity, related compounds suggest possible harm to aquatic life
Persistence and Degradability: Likely not readily biodegradable
Bioaccumulative Potential: No significant data; molecular structure indicates potential moderate bioaccumulation
Mobility in Soil: Partitioning favors retention in soil organic matter, low water solubility
Other Adverse Effects: Prevent from entering waterways or drains
Waste Disposal Methods: Treat as hazardous, incinerate via a chemical waste facility, follow local and national guidelines
Container Disposal: Rinse packaging thoroughly, destroy by incineration or approved hazardous waste processor
Contaminated Packaging: Handle as hazardous waste
Recommendation: Do not pour into drains, avoid landfills, use licensed waste contractor
UN Number: Not specifically assigned, ship as chemical, liquid, n.o.s. under relevant regulations
Transport Hazard Class: Not regulated as dangerous goods by IATA, IMDG, ADR for limited quantities; check supplier details
Proper Shipping Name: Tert-Butyl 4-Bromobutyrate
Packing Group: Consult shipping company guidelines
Hazards During Transport: Keep away from food and feedstuffs, avoid high temperatures, secure upright to prevent leaks
Special Precautions: Label package with chemical name and hazard warnings
OSHA Status: Not specifically regulated, handle following OSHA standards for hazardous substances
TSCA: Listed or covered under appropriate CAS
REACH: Registration or notification required above set volume limits in EU
SARA Title III: Not subject to reporting as extremely hazardous; check specific State or local lists
California Proposition 65: Not listed
Other Inventory Listings: EINECS/ELINCS: registered; consult Safety & Environmental department for regional compliance
Workplace Labeling: Clear hazard statements, GHS pictograms, product identity required
