Product Name: Tetramethyl Ammonium Dihydrogen Phosphate
Synonyms: TMADP
Chemical Family: Quaternary ammonium compound, inorganic phosphate
CAS Number: 3594-78-1
Manufacturer: Information available on request
Recommended Use: Laboratory reagent, chemical intermediate, specialty chemical manufacturing
Emergency Contact: Refer to national Poison Control or manufacturer’s hotline
GHS Classification: Acute Oral Toxicity Category 4, Eye Irritation Category 2A, Skin Irritation Category 2
Label Elements: Pictogram: Exclamation mark; Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes eye irritation, causes skin irritation
Precautionary Statements: Do not eat, drink or smoke when using; wash hands thoroughly after handling; wear eye and face protection; avoid breathing dust or vapor; use only outdoors or in a well-ventilated area
Hazard Overview: Direct contact with the solid or solutions can lead to redness, burning in eyes and skin, or gastric discomfort and vomiting after ingestion. Dust may irritate respiratory tract and provoke coughing. Spillage increases slip risk.
Chemical Identity: Tetramethyl Ammonium Dihydrogen Phosphate
Formula: C4H16NO4P
Molecular Weight: 185.16 g/mol
Concentration: 98–100% pure substance
Impurities: Water (<1%), trace organic solvents (<0.5%)
Inhalation: Move exposed worker to fresh air, keep breathing steady, rinse mouth and consult physician for persistent irritation.
Skin Contact: Immediately remove contaminated clothing, rinse affected skin under running water at least 15 minutes, seek medical advice if irritation appears.
Eye Contact: Lift eyelids and flush eyes gently with clean water for at least 15 minutes, remove contact lenses if present, keep rinsing, obtain medical attention in case of discomfort or visual disturbance.
Ingestion: Rinse mouth with water, do not provoke vomiting, administer water if person remains alert, call Poison Control or physician promptly.
Most Important Symptoms: Burning sensation, pain, redness, headache, nausea, dizziness, drowsiness, vision change.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray (fog), alcohol-resistant foam
Specific Hazards: Decomposes under fire to form gases like nitrogen oxides, methylamine, phosphorus oxides, carbon oxides; can produce toxic fumes
Special Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Explosion Data: Material does not present specific explosion risk but fine dust can accumulate and combust under strong ignition
Measures: Move containers from fire area if safe, prevent firefighting water from entering drains.
Personal Precautions: Evacuate area, ventilate, prevent dust formation, use gloves, chemical goggles and dust respirator, avoid direct contact
Environmental Precautions: Prevent release to water sources or soil, dike spill with absorbent materials, do not wash into drains
Cleanup Methods: Scoop up powder with non-sparking tools, place in labeled waste containers, wash residues with plenty of water
Disposal: Follow federal, state and local regulations, seek chemical waste disposal specialist.
Handling: Use chemical resistant gloves, safety glasses and lab coats; avoid dust and inhalation, open containers with care, wash thoroughly before meals and after handling; keep away from incompatible materials like strong acids or oxidizers
Storage: Store in tight, clearly labeled, corrosion-resistant containers, away from food or feed, keep dry and below 25°C, separate from acids and flammable materials, maintain good ventilation in storage area
Incompatible Materials: Strong acids, alkalis, oxidizing agents, strong reducing materials
Special Considerations: Store away from protected environments; maintain spill containment in storage rooms.
Occupational Exposure Limits: No established OSHA limits, minimize exposure as low as possible
Engineering Controls: Use under chemical fume hood, provide eyewash and safety shower, ensure good general room ventilation
Personal Protective Equipment:
- Eyes: Tight-fitting chemical goggles, face shield
- Skin: Resistant gloves (nitrile or neoprene), full-length lab coat
- Respiratory: Dust mask or half-mask respirator (NIOSH approved) if handling large quantities or in dust-prone spaces
General Hygiene: Remove contaminated clothing, wash hands after handling, do not eat or drink near chemical, avoid skin/eye contact.
Appearance: White crystalline solid or powder
Odor: Mild, slightly fishy
Odor Threshold: Not established
pH (1% Solution): Approximately 3 – 5
Melting Point/Range: 170–175°C (decomposes)
Boiling Point: Not applicable (decomposes)
Flashpoint: Not established
Evaporation Rate: Not applicable
Flammability: Not flammable under normal conditions
Vapor Pressure: Very low at room temperature
Solubility: Highly soluble in water, partially soluble in ethanol
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not applicable
Decomposition Temperature: Above 170°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended handling and storage conditions, sensitive to moisture and strong heat
Reactivity: Reacts with strong oxidizers and acids, may react with bases to form tetramethylammonium hydroxide
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, methylamines, phosphorus oxides
Conditions to Avoid: High temperatures, flame, sparks, direct sunlight, uncontrolled discharge in water
Polymerization: Does not polymerize
Corrosivity: Can corrode certain metals in presence of moisture
Acute Toxicity (Oral): LD50 (oral, rat): about 400 mg/kg, may cause nausea, vomiting, diarrhea, abdominal pain
Acute Toxicity (Dermal/Inhalation): No specific data, avoid all exposure
Skin Corrosion/Irritation: Can cause redness, pain, drying, and irritation on prolonged or repeated contact
Serious Eye Damage/Irritation: Causes painful burning, watering, risk of corneal injury
Respiratory/Reproductive/Sensitization: Single exposure can cause nasal or respiratory tract irritation, coughing, headache; no evidence of reproductive toxicity or sensitization reported
Chronic Effects: Limited chronic data, repeated misuse can aggravate respiratory, kidney or liver conditions
Carcinogenicity: Not classified as carcinogen by IARC, ACGIH, NTP or OSHA
Mutagenicity/Teratogenicity: No reliable studies reported
Eco-toxicity: Toxic to aquatic life in high concentrations, sensitive to fish and invertebrates (LC50 values not fully established)
Persistence/Degradability: Not readily biodegradable, quaternary ammonium compounds can persist in environment
Bioaccumulative Potential: Low mobility in soil, weak bioaccumulation expected due to ionic nature
Mobility in Soil: Water soluble, may migrate into groundwater if released in large amounts
Other Adverse Effects: Can raise phosphate and amine levels in water, leading to nutrient pollution and algal blooms in sensitive locations
Waste Treatment Methods: Dispose through licensed hazardous waste contractor, never pour into sewage or regular trash
Container Disposal: Rinse empty containers three times, then puncture or destroy before appropriate landfill or incineration, check local legislation
Special Precautions: Wear full protective gear when handling residues, label as hazardous chemical waste, coordinate with environmental officials to reduce potential for accidental release or misidentification.
UN Number: 2811 (Toxic Solid, Organic, N.O.S.)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (lower danger)
Labeling Requirements: Toxic substance label (skull and crossbones), keep clear of food transport
Special Precautions: Secure upright, don’t stack with incompatible chemicals, transport with full documentation including emergency contact card
Environmental Hazards: Not a marine pollutant but keep away from water supplies
Emergency Response: In case of spill, restrict area and use recommended personal protection and cleanup steps.
Regulatory Status: Subject to chemical safety and environmental legislation such as OSHA, TSCA (US), WHMIS (CA), REACH (EU)
Inventory Listings: Listed on TSCA Inventory, EINECS/ELINCS inventory
SARA Title III (Sections 302/313): Not listed as extremely hazardous or reportable, but best practice calls for reporting significant releases
California Proposition 65: Not identified as known carcinogen or reproductive toxicant
Other National Regulations: May be subject to workplace exposure and disposal limits in many countries, review relevant local safety codes.
