Product Name: Tetramethylammonium Bromide
Synonyms: TMAB, N,N,N-Trimethylmethanaminium Bromide
Chemical Formula: C4H12BrN
CAS Number: 64-20-0
Recommended Uses: Laboratory reagent, chemical synthesis, phase transfer catalyst
Supplier: Contact information and emergency phone number can be found on the original packaging or purchase documents for proper emergency communication.
GHS Classification: Acute Toxicity (Oral) - Category 3; Acute Toxicity (Dermal) - Category 3; Skin Irritation - Category 2; Eye Irritation - Category 2A
Pictograms: Skull and Crossbones, Exclamation Mark
Signal Word: Danger
Hazard Statements: Toxic if swallowed or in contact with skin; Causes skin and serious eye irritation
Precautionary Statements: Wash thoroughly after handling, do not eat, drink or smoke during use, avoid contact with eyes, skin, and clothing, wear protective gloves, protective clothing, and eye/face protection
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Nervous system, mucous membranes
Chemical: Tetramethylammonium Bromide
CAS Number: 64-20-0
Concentration: 100%
Molecular Weight: 194.06 g/mol
Impurities: Not expected under normal manufacturing practices; check certificate of analysis for batch specifics
Stabilizers/Additives: None
Inhalation: Remove person to fresh air as soon as possible and seek medical attention if symptoms like headache, dizziness, or difficulty breathing arise. Do not allow victim to lose consciousness before help arrives.
Skin Contact: Remove contaminated clothing. Rinse immediately with plenty of water for at least fifteen minutes. Get medical help if irritation or toxicity signs show up.
Eye Contact: Gently rinse eyes with water for several minutes, keeping eyelids open. Remove contact lenses if present and easy to do; continue rinsing. Get prompt medical evaluation.
Ingestion: Rinse mouth thoroughly with water. Never give anything by mouth to an unconscious person. Do not induce vomiting unless advised by a medical professional. Call a poison center or physician immediately.
Acute Symptoms: Nausea, vomiting, convulsions, irritation of mouth and throat, drowsiness
Immediate Medical Attention Required: Yes, in cases of significant ingestion, contact with skin, or inhalation of large amounts
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, or water spray for larger fires
Unsuitable Extinguishing Media: Strong water jets may spread the material; avoid direct streams
Special Hazards: Emits toxic fumes like nitrogen oxides, methylamine, carbon monoxide, and hydrogen bromide under fire conditions; combustion may release irritants
Protective Equipment for Firefighters: Full protective suit and self-contained breathing apparatus in enclosed spaces
Firefighting Guidance: Move containers from fire area if safely possible, keep containers cool with water spray to avoid pressure buildup, contain runoff as it may be hazardous
Personal Precautions: Evacuate unnecessary personnel, ventilate affected area, avoid dust formation and inhalation, wear appropriate personal protective equipment
Environmental Precautions: Prevent substance from entering drains, watercourses or soil. Notify authorities if spill results in environmental contamination
Cleaning Up: Collect powder or crystals using non-sparking tools, sweep into suitable container for disposal according to local regulations, wash contaminated area with water, avoid raising dust during cleanup
Disposal Materials: Use non-combustible, sealable containers to prevent re-entry into workplace
Handling: Keep containers tightly sealed, handle in a chemical fume hood or well-ventilated space, wear proper PPE like gloves and goggles, avoid generating dust, wash hands thoroughly after handling
Incompatible Materials: Oxidizers and strong acids, strong reducing agents, avoid contact with moisture
Safe Storage Conditions: Store in original, tightly sealed containers kept in a dry, cool, and well-ventilated area. Protect from sunlight, heat sources, and incompatible substances to reduce the possibility of hazardous decomposition
Storage Class: Toxics storage according to local regulations, segregate from food and drink
Control Parameters: No workplace exposure limits have been established, monitor dust levels in the air, consult national/local authorities for occupational exposure limits
Engineering Controls: Use local exhaust ventilation or chemical fume hoods; maintain eye wash stations and showers in the work area for emergencies
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile recommended), lab coat or apron, safety goggles or face shield, approved respirator if dust or aerosol is generated
Hygiene Measures: Remove contaminated clothing before leaving the work area, wash hands, forearms, and face after handling
Appearance: White crystalline powder
Odor: Odorless
pH (5% solution): 6.0–8.0 at 20°C
Melting Point/Freezing Point: 232–235°C (dec)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (non-flammable solid)
Flammability: Not flammable; may support combustion under intense heat
Vapor Pressure: Negligible at room temperature
Solubility: Freely soluble in water, alcohol, and chloroform
Partition Coefficient (n-octanol/water): Not determined
Density: Around 1.5 g/cm³
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 235°C
Viscosity: Not applicable
Chemical Stability: Stable under normal handling and storage conditions if kept dry and away from incompatible substances
Reactivity: Reacts with strong oxidizing agents, acids, and may react with moisture producing toxic gases
Conditions to Avoid: Excessive heat, open flames, exposure to moisture, incompatible substances
Hazardous Decomposition Products: Methylamine, hydrogen bromide, nitrogen oxides, carbon monoxide
Polymerization: Will not occur
Likely Routes of Exposure: Ingestion, skin contact, eye contact, inhalation of dust
Acute Toxicity: LD50 (oral, rat): 41 mg/kg; LD50 (dermal, rabbit): data limited, but known to be low
Skin Corrosion/Irritation: Irritating to skin; may cause redness, pain
Serious Eye Damage/Irritation: Causes serious eye irritation, risk of permanent damage if exposure is significant
Respiratory Sensitization: Data insufficient, but inhalation of dust can cause respiratory discomfort
Germ Cell Mutagenicity: No information available
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Reproductive Toxicity: No data available
STOT-single Exposure: Can cause drowsiness or dizziness
STOT-repeated Exposure: Data not established
Aspiration Hazard: Not classified
Symptoms of Overexposure: Symptoms include nausea, sweating, muscle spasms, convulsions, and even fatal toxicity at high doses
Ecotoxicity: Toxic to aquatic life, may cause long-term adverse effects in aquatic environments; avoid release of material into waterways
Persistence and Degradability: Not readily biodegradable, persistent in aquatic and soil environments
Bioaccumulative Potential: Low potential due to high solubility; unlikely to bioaccumulate
Mobility in Soil: High mobility in water; can leach to groundwater if improperly disposed
Other Adverse Effects: Toxic to algae, daphnia, and fish in laboratory settings; lack of sufficient real-world ecological studies
Waste Treatment Methods: Dispose of material in accordance with local, regional, and national regulations
Container Disposal: Rinse container before disposal, do not reuse, ensure complete removal of all residues
Special Precautions for Disposal: Handle under supervision of properly trained individuals, incineration at approved facilities is recommended
Waste Code: Contact local authorities for waste code assignments
UN Number: 2811
UN Proper Shipping Name: Toxic Solid, Organic, n.o.s. (Tetramethylammonium Bromide)
Transport Hazard Class: 6.1
Packing Group: III
Marine Pollutant: Not classified as a marine pollutant under IMDG
Special Precautions: Handle sealed and labeled containers with care, consult latest transport regulations before shipping
Transportation Labels: Toxic (skull and crossbones), keep away from food and feed
OSHA Status: Hazardous according to OSHA Hazard Communication Standard
SARA Title III Sections 311/312: Acute Health Hazard
Inventory Status: Listed on TSCA (US), EINECS (Europe), DSL (Canada), and other major regulatory agency chemical inventories
Right-to-Know Regulations: Subject to reporting requirements in certain states or countries
Additional Regulations: Refer to country-specific requirements regarding workplace exposure, labeling, and safe handling
Document Prepared According To: Globally Harmonized System (GHS) of Classification and Labeling of Chemicals
