Product Name: Tetramethylammonium Hydrogen Sulfate
Chemical Formula: C4H13NO4S
Synonyms: TMAHS, Tetramethylammonium bisulfate
CAS Number: 567-65-1
Recommended Uses: Laboratory reagent, organic synthesis, phase transfer catalyst
Supplier Information: Supplier details should be provided with contact number for emergencies.
GHS Classification: Acute Toxicity, Category 4 (Oral), Eye Irritation, Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this product. Wear protective gloves/eye protection.
Substance: Tetramethylammonium Hydrogen Sulfate
CAS Number: 567-65-1
Concentration: 100% (pure substance product)
Impurities: May contain trace levels of other ammonium salts depending on source.
Inhalation: Move to fresh air, stay at rest, seek medical advice if symptoms develop.
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water, seek medical attention for persistent irritation.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing. Get medical attention immediately for persistent pain or vision issues.
Ingestion: Rinse mouth, avoid induction of vomiting, seek medical help immediately. Symptoms may include nausea, vomiting, and abdominal pain.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or alcohol-resistant foam. Water spray may be used to cool exposed containers.
Special Hazards Arising from the Substance: Thermal decomposition may produce nitrogen oxides, sulfur oxides, toxic fumes.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear. Evacuate area if fumes become extensive.
Personal Precautions: Avoid dust formation. Provide adequate ventilation. Use appropriate personal protective equipment.
Environmental Precautions: Prevent entry into drains, waterways, soil.
Methods for Clean-up: Sweep up and place in suitable, labeled containers for disposal. Wash affected area with water. Do not create dust clouds.
Handling: Use only with adequate ventilation. Avoid contact with skin, eyes, and clothing. Prevent formation of dust. Do not eat, drink, or smoke around the substance.
Storage: Keep in tightly closed container, store in cool, dry, and well-ventilated area. Store away from incompatible materials such as strong bases or oxidizing agents. Protect from moisture.
Exposure Limits: No occupational exposure limits established, but minimize workplace concentrations.
Engineering Controls: Use local exhaust ventilation, eye wash stations, and safety showers.
Personal Protection: Wear protective gloves, chemical safety goggles, lab coat, and, for large-scale use, NIOSH-approved respirator. Wash hands before breaks and after handling.
Appearance: White crystalline solid
Odor: No significant odor
Melting Point: 190 – 195 °C
Solubility: Highly soluble in water
pH (1% solution): Slightly acidic, around 4
Boiling Point: Decomposes before boiling
Relative Density: 1.22 – 1.23 g/cm³
Vapor Pressure: Not applicable (non-volatile solid)
Partition Coefficient: Not available
Flash Point: Not flammable
Autoignition Temperature: Not relevant for inorganic salts
Viscosity: Not applicable for solids
Chemical Stability: Stable under recommended storage conditions. Decomposes upon strong heating.
Reactivity: Incompatible with strong bases, strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, toxic gases.
Conditions to Avoid: Extreme heat, moisture, incompatible materials.
Polymerization: Does not occur.
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: May cause irritation to skin, eyes, respiratory tract. Ingestion may cause nausea, vomiting, abdominal pain.
Acute Toxicity: LD50 (Oral): Estimated 100–300 mg/kg (rat, by analogy with similar compounds).
Chronic Effects: Prolonged or repeated exposure can increase risk of sensitization and organ effects.
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA.
Mutagenicity and Reproductive Toxicity: Data limited, no evidence for significant effects in available studies.
Other Effects: Overexposure may cause disturbances of the nervous system due to quaternary ammonium compounds’ activity.
Ecotoxicity: Toxic to aquatic life at high concentrations. Discharge to the environment should be minimized to prevent potential water pollution.
Persistence and Degradability: No rapid biodegradation. Persists in the environment.
Bioaccumulation: Not likely to bioaccumulate based on water solubility and molecular structure.
Mobility in Soil: Highly mobile due to high solubility in water.
Other Adverse Effects: No other specific environmental hazards identified, but minimize uncontrolled release.
Waste Treatment Methods: Dispose of according to federal, state, and local environmental regulations.
Disposal of Product: Small quantities can be diluted with plenty of water and discarded to drain if allowed by local regulations. Otherwise, send to a licensed chemical waste disposal contractor.
Disposal of Contaminated Packaging: Rinse and dispose in compliance with official requirements.
Additional Information: Do not discharge to environment. Coordination with local hazardous waste authorities is recommended.
UN Number: Not regulated for most modes of transportation, but check local and international regulations.
Proper Shipping Name: Tetramethylammonium Hydrogen Sulfate
Transport Hazard Class: Not classified for transport hazard
Packing Group: Not applicable
Marine Pollutant: Not listed as marine pollutant
Special Precautions: Avoid release to environment during transport. Ensure packaging prevents water ingress and accidental release.
EU Regulations: Not specifically listed under REACH Annex XVII or XIV. General requirements for chemicals apply.
US Regulations: Not listed on the US TSCA Inventory as a restricted substance. Not categorized as hazardous waste under RCRA.
Workplace Regulations: Follow OSHA’s chemical hygiene plan and hazard communication standards.
Labeling Requirements: Product labels must reflect hazard communication under OSHA, CLP, GHS requirements including warnings and pictograms.
Other Applicable Legislation: Local workplace safety and chemical management codes may apply depending on jurisdiction.
