Product Name: Tetramethylguanidine Acetate
Chemical Formula: C6H16N3O2
Synonyms: N,N,N’,N’-Tetramethylguanidine Acetate
CAS Number: 15373-71-0
Use: Laboratory reagent, organic synthesis
Supplier Information: Manufacturer and distributor addresses, emergency contact numbers, date of issue must be clearly stated
GHS Classification: Skin Corrosive (Category 1B), Serious Eye Damage (Category 1), Acute Toxicity Oral (Category 4)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; Harmful if swallowed
Precautionary Statements: Avoid breathing dust or fumes; Wash thoroughly after handling; Wear protective gear such as gloves, clothing, and eye protection; Seek immediate medical assistance if ingested, inhaled, or in direct contact
Pictograms: Corrosive, Exclamation Mark
Target Organs: Eyes, skin, gastrointestinal tract
Chemical Name: Tetramethylguanidine Acetate
CAS No.: 15373-71-0
Concentration: 98-100%
Impurities: Trace solvents or related guanidine byproducts, data sheet from manufacturer usually shows ingredients above threshold levels
Inhalation: Move person to fresh air, keep breathing easy, call medical help if symptoms develop or persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water ideally for at least 15 minutes, call a physician if irritation or chemical burn occurs
Eye Contact: Rinse cautiously with water for several minutes, lift eyelids to ensure thorough rinsing, consult a doctor immediately
Ingestion: Rinse mouth, do not induce vomiting, call poison control and get medical help without delay
Most Important Symptoms: Burning, irritation, coughing, gastric pain, tissue damage
Suitable Extinguishing Media: Use dry chemical powder, CO2, alcohol-resistant foam for small fires; for larger quantities water spray
Unsuitable Extinguishing Media: Do not use water jet, as it may spread chemical
Special Protective Equipment: Full firefighting turn-out gear, self-contained breathing apparatus
Hazards from Combustion: Irritating or toxic fumes such as nitrogen oxides, carbon oxides; acetate decomposition can release acetic acid vapors
Advice for Firefighters: Keep upwind, prevent runoff from entering drains or watercourses
Personal Precautions: Avoid skin and eye contact, prevent inhalation of dust/faume, ensure proper ventilation, wear chemical resistant gloves and goggles
Environmental Precautions: Keep spills out of sewers and surface water, isolate affected area
Clean-up Methods: Contain spill with inert material (sand, earth), collect and transfer to clearly labeled waste container, clean surface thoroughly after pickup, dispose of waste according to official local regulations
Handling: Use in well-ventilated areas, avoid contact with skin and eyes, do not eat, drink or smoke while using, use appropriate protective equipment, ensure containers are tightly closed when not in use
Storage Conditions: Store in a cool, dry, well-ventilated location away from incompatible substances such as strong oxidizing agents and acids, keep away from direct sunlight and foodstuffs, segregate from materials that can catch fire or react with strong bases
Storage Class: Store alongside basic and corrosive substances—review segregations1
Exposure Limits: No established OSHA or ACGIH limits; minimize exposure at all times
Engineering Controls: Use fume hood, local exhaust, safety showers, and eyewash stations
Personal Protective Equipment (PPE): Chemical-resistant gloves (such as butyl rubber), splash-proof goggles, lab coats, closed-toe shoes, face shield for large quantities
Respirators: Use NIOSH-approved respirator if handling powder or dust in poorly ventilated spaces
Appearance: White to off-white crystalline solid
Odor: Mild, ammonia-like
Molecular Weight: 162.22 g/mol
Melting Point: Approximately 110°C (230°F)
Boiling Point: Decomposes before boiling
Solubility: Readily soluble in water; soluble in alcohol and some organic solvents
pH: Strongly basic, pH above 10 in aqueous solution
Vapor Pressure: Not significant at room temperature
Density: Approx. 1.10 g/cm³
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Reacts with strong acids forming heat and volatile guanidine; may react with oxidizing agents
Hazardous Decomposition: Carbon oxides, nitrogen oxides, irritating vapors, acetate may emit acetic acid
Conditions to Avoid: Exposure to moisture, strong acids, heat above melting point
Incompatible Materials: Strong acids, oxidizers, acid chlorides
Acute Toxicity: Harmful if swallowed (oral LD50 with similar guanidines: rat at 300-2000 mg/kg)
Skin Corrosion/Irritation: Severe skin burns possible on contact
Serious Eye Damage: Severe and rapid tissue corrosion
Inhalation Risks: Irritation of respiratory tract, coughing, difficulty breathing if dust or vapors inhaled
Chronic or Delayed Effects: Repeated exposure can cause contact dermatitis, no definitive evidence for reproductive or mutagenic effects due to lack of large-scale studies
Toxicity to Aquatic Life: Harmful to aquatic organisms at acute exposure; laboratory observations show disruption in algae and invertebrate growth
Persistence and Degradability: Breaks down in presence of water and aerobic bacteria, but components, including acetate, can contribute to oxygen demand in water; basic guanidines persist longer in soil
Bioaccumulation Potential: Not measured to bioaccumulate significantly
Mobility in Soil: Water soluble; expected to move through soil, potential groundwater contaminant if spilled in large quantities
Other Effects: Raises pH in water, can damage aquatic habitats
Disposal Methods: Place material and all contaminated items in properly labeled chemical waste container, send for incineration or specialized landfill according to local, regional, and national rules
Do Not: Pour into public drains or water systems
Container Disposal: Triple rinse, puncture, and remove labels before recycling or handling as hazardous waste
Consideration: Consult local environmental authorities before disposal to verify all requirements
UN Number: 3263
Proper Shipping Name: Corrosive Solid, Basic, Organic, N.O.S. (Tetramethylguanidine Acetate)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Environmental Hazards: Not marine pollutant
Transport Precautions: Keep container upright, dry, tightly sealed, describe exact hazard on shipping papers
Regulatory Reference: Road, Air, Sea: Comply with ADR, IATA, IMDG codes
OSHA: Handle as hazardous, ensure compliance with worker safety and hazard communication rules
TSCA: Tetramethylguanidine Acetate listed for research and development use
SARA Title III: Not specifically listed under sections 302, 304, 313; report significant releases per local requirements
REACH: Data may be registered under precursor guanidine compounds
Local Requirements: Users must check national and regional laws, disclosure and handling rules change significantly by locality
Labeling: GHS hazard symbols, ingredient listing, precautionary statements essential for workplace compliance
