Product Name: Tetramethylguanidine Chloride
Synonyms: TMG chloride
CAS Number: 2246-24-2
Recommended Use: Intermediate for chemical synthesis, laboratory reagent
Supplier: [Contact details for manufacturer or distributor]
Emergency Telephone Number: [Provided by supplier]
GHS Classification: Acute toxicity (oral), category 3; Skin corrosion/irritation, category 1B; Serious eye damage/eye irritation, category 1
Label Elements: Signal Word: Danger; Hazard Statements: Toxic if swallowed, causes severe skin burns and eye damage
Precautionary Statements: Avoid breathing dust or vapors; Wash skin thoroughly; Wear protective gloves, protective clothing, eye protection, face protection
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Additional Information: Strongly corrosive to mucous membranes, may cause burns and respiratory distress
Chemical Name: Tetramethylguanidine Chloride
Concentration: >98% (by weight)
Molecular Formula: C5H13N3·Cl
Impurities or Additives: None identified above 1% threshold
EC Number: 218-874-0
Inhalation: Move victim to fresh air immediately. Seek medical attention if symptoms persist or develop. Support respiration if required.
Skin Contact: Remove contaminated clothing. Rinse affected area with plenty of water for 15 minutes. Get prompt medical attention.
Eye Contact: Flush eyes thoroughly with water for at least 15 minutes, lifting eyelids to ensure complete irrigation. Obtain medical care without delay.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Offer water to drink only if person is fully conscious. Immediate medical assistance required.
Symptoms: Burning sensation, redness, blisters, coughing, shortness of breath; may progress to severe irritation or tissue destruction
Suitable Extinguishing Media: Dry chemical foam, carbon dioxide, or water spray
Unsuitable Extinguishing Media: Do not use a direct water jet
Specific Hazards: Produces toxic and corrosive fumes, including nitrogen oxides and hydrogen chloride
Protective Equipment for Firefighters: Use full protective clothing and self-contained breathing apparatus
Special Procedures: Keep persons away from and upwind of fire; cool containers exposed to flame with water spray to prevent rupture
Personal Precautions: Evacuate non-essential personnel. Provide adequate ventilation. Avoid breathing dust or vapors. Wear suitable protective equipment including gloves, goggles, and chemical-resistant clothing.
Environmental Precautions: Prevent product from entering drains, surface water, and soil; contain spill to the extent possible
Cleanup Methods: Shovel spilled material into suitable, labeled containers for disposal with non-sparking tools; Wash area with plenty of water; ventilate the area; Dispose of waste in accordance with local and national regulations.
Emergency Procedures: Notify relevant authorities if spill has caused environmental contamination or poses an immediate hazard
Handling Recommendations: Use in well-ventilated areas. Avoid contact with eyes, skin, and clothing. Do not ingest or inhale. Open containers carefully, as pressure may build up inside. Do not eat, drink, or smoke while handling.
Storage Conditions: Store tightly sealed in a cool, dry, and well-ventilated place away from direct sunlight, heat, and incompatible materials such as acids and oxidizing agents; Segregate from food and feedstuffs to avoid accidental ingestion
Packaging Materials: Use corrosion-resistant containers with secure closures
Incompatibilities: Strong acids, strong oxidizing agents, moisture-sensitive substances
Control Parameters: No occupational exposure limit values have been established.
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below occupational exposure limits
Personal Protective Equipment: Respiratory protection (NIOSH/MSHA approved respirator), chemical safety goggles or face shield, chemical-resistant gloves (nitrile, neoprene), full-body protective clothing, and appropriate footwear
Hygiene Measures: Wash hands before eating, drinking, or using restrooms; Remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline solid
Odor: Not significant or faintly amine-like
Melting Point: Approximately 148-150 °C
Boiling Point: Decomposes before boiling
Solubility: Highly soluble in water, soluble in polar organic solvents
pH (aqueous solution): Strongly basic
Vapor Pressure: Not available
Density: Approximately 1.08 g/cm³ at 25 °C
Flash Point: Not applicable
Auto-ignition Temperature: Data not available
Partition Coefficient (log Kow): Data not available
Decomposition Temperature: > 150 °C, may release toxic fumes
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts violently with strong acids producing heat and toxic gases
Hazardous Reactions: Contact with oxidizing agents or acids increases risk of hazardous decomposition
Conditions to Avoid: Moisture, open flames, sources of ignition, direct sunlight, incompatible materials
Hazardous Decomposition Products: Ammonia, nitrogen oxides, hydrogen chloride, other toxic vapors
Polymerization: No known hazardous polymerization
Acute Toxicity: LD50 (oral, rat): approximately 55 mg/kg
Skin Corrosion/Irritation: Causes severe burns with tissue destruction
Serious Eye Damage: Risk of permanent eye damage or blindness
Respiratory Sensitization: Not sensitizing, but inhalation of dust causes severe irritation, coughing, and difficulty breathing
Carcinogenicity: Not classified as carcinogen
Mutagenicity: No data available
Other Effects: Contact produces immediate pain, redness, swelling, blistering; Severe exposure may lead to tissue necrosis
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, respiratory irritation
Eco-toxicity: Harmful to aquatic organisms due to possible pH shifts and toxicity
Persistence and Degradability: Data not available; likely to degrade slowly in water
Bioaccumulative Potential: Expected to have low bioaccumulation due to high water solubility
Mobility: High mobility in soil and water because of its solubility
Other Adverse Effects: Significant spillages may damage aquatic environments and soil microflora; Prevent release to environment
Disposal Methods: Dispose of in accordance with local, regional, and national regulations via an authorized chemical waste contractor
Contaminated Packaging: Rinse thoroughly and dispose of as hazardous waste
Special Precautions: Do not incinerate in open air; Do not allow to reach sewage system or water courses
Recommended Waste Codes: Assign according to national, regional, or local regulations for hazardous chemical waste
UN Number: 3263
UN Proper Shipping Name: Corrosive solid, basic, organic, n.o.s. (Tetramethylguanidine Chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Segregate from acids; transport in tightly closed, secure containers
Safety, Health, and Environmental Regulations: Classified as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200); Listed in the TSCA Inventory; Subject to applicable SARA Title III requirements
Labeling Requirements: Use GHS/CLP compliant labeling for containers; Include hazard pictograms, signal word, hazard and precautionary statements
REACH Registration: Not fully assessed for all possible uses
Other Regulatory Standards: Handle according to local, national, and international chemical safety regulations; Consult authorities for additional competency training and statutory notifications if required
