Product Name: Tetramethylguanidine Dihydrogen Phosphate
Chemical Formula: C5H17N3O4P
Synonyms: TMG·H2PO4
Recommended Use: Laboratory chemicals and industrial manufacturing processes
Supplier Identification: Producer or distributor details included on packaging label
Contact for Emergency: Refer to manufacturer; typically includes 24/7 emergency phone for incidents involving spills or exposure
CAS Number: 881049-49-0
UN Number: Not listed under UN recommendations
Email for MSDS Information: Direct inquiry to producer's posted contact
Classification: Irritant (H315 Skin irritation, H319 Serious eye irritation); Harmful if swallowed or inhaled
Label Elements: Pictograms for exclamation mark for irritation, hazard statements cover skin and eye irritation, precautionary statements outline avoidance of breathing dust or fumes
Potential Health Effects: Contact can cause redness, itching, and burns to skin or eyes; inhalation leads to throat irritation and coughing; ingestion results in abdominal pain and nausea
Environmental Hazards: Not classified as environmentally hazardous; aquatic toxicity considered low, but prevent bulk releases
Other Hazards: Substance not combustible but decomposes at high temperatures to release toxic fumes such as nitrogen oxides and phosphoric acid vapors
Chemical Name: Tetramethylguanidine Dihydrogen Phosphate
CAS Number: 881049-49-0
Concentration: 98% or higher w/w
Impurities: Trace methylamine compounds & water (<2% combined)
Molecular Weight: 211.18 g/mol
Eye Contact: Flush with water for 15 minutes; lift eyelids to rinse thoroughly; seek immediate medical advice
Skin Contact: Remove contaminated clothing; rinse skin with plenty of water; wash with mild soap if available; consult physician for prolonged irritation
Inhalation: Move to fresh air right away; keep person comfortable; obtain medical attention if symptoms occur
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical attention at once; show product label if possible
Important Symptom Information: Watch for burning, pain, respiratory difficulty, or decreased alertness; report symptoms to healthcare provider promptly
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, or alcohol-resistant foam work best
Unsuitable Media: Avoid direct water jet on product; risk of spreading contamination
Special Hazards During Fire: Product does not burn easily, but heating causes release of irritating gases such as nitrogen oxides, phosphorus oxides
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective suit
Firefighting Instructions: Remove containers from fire zone if safe; cool containers with water mist to prevent rupture; prevent runoff from entering drains
Personal Precautions: Wear chemical-resistant gloves, safety goggles, respiratory protection if dust or fumes present; avoid direct contact
Environmental Precautions: Prevent further leakage; do not allow material to enter surface water, sewer or soil in large volumes
Containment: Sweep up spills using non-sparking tools; transfer to dry, sealable containers for cleanup and disposal
Cleaning Method: Ventilate area; use absorbent material for residues; wash spill area with plenty of water
Notification: Inform environmental authorities if spillage or environmental contamination occurs
Handling: Operators wear approved PPE; minimize exposure to dust and handling in well-ventilated areas; do not eat, drink, or smoke around product
Safe Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area; keep away from heat sources, oxidizing agents, and acids
Incompatibilities: Keep away from strong oxidizers, reducers, acids and bases; incompatible with moisture—store desiccated
Special Precautions: Segregate from food and feedstuffs in warehouse; signage for hazardous materials on storage units
Handling Procedures: Avoid creating dust; use containment systems for bulk transfer
Occupational Exposure Limits: No specific limits set by OSHA, ACGIH, or EU, but control exposure to lowest practicable level
Engineering Controls: Use chemical fume hoods, eyewash stations, and safety showers in working areas
Personal Protective Equipment: Safety goggles, face shield, chemical-resistant gloves (nitrile or neoprene), lab coat, and dust mask or respirator
Hygiene Measures: Wash hands after handling; avoid contact lenses when using this product
Environmental Controls: Manage exhaust gases or vapors with appropriate scrubbers; HEPA filters on air intakes and exhausts recommended
Appearance: White to off-white crystalline powder
Odor: Ammonia-like or fishy when moist
Odor Threshold: Low; irritant at low concentrations
pH: Acidic in solution (2.0–3.0 at 10%)
Melting Point: 178–180°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water; limited in ethanol
Vapor Pressure: Negligible under ambient conditions
Relative Density: 1.35 g/cm³
Evaporation Rate: Not relevant
Partition Coefficient (n-octanol/water): Log Kow estimated <0
Flash Point: Not flammable
Explosion Limits: Not explosive
Decomposition Temperature: >180°C, releasing toxic gases
Viscosity: Not applicable, solid form
Chemical Stability: Remains stable under recommended storage and handling conditions
Hazardous Reactions: Reacts with strong oxidizers, acids, alkalis, with risk of hazardous decomposition
Conditions to Avoid: High temperatures, moisture, direct sunlight
Materials to Avoid: Strong oxidizers, mineral acids, reducing agents
Decomposition Products: Nitrogen oxides, phosphoric acid vapors, carbon oxides, methylamines
Acute Toxicity: Low oral and dermal toxicity reported in animal studies; irritant at moderate concentrations
Skin Corrosion / Irritation: Causes moderate to strong irritation; repeat contact increases severity
Serious Eye Damage / Irritation: Produces severe pain and conjunctival redness; risk of lasting injury
Respiratory Sensitization: Dust and aerosol inhalation may cause coughing, difficulty breathing, nose or throat irritation
Germ Cell Mutagenicity: No known genotoxicity from public studies
Carcinogenicity: No data showing carcinogenic risk to humans or animals
Reproductive Toxicity: No adverse reproductive effects observed in limited existing data
STOT-Single and Repeated Exposure: Short-term exposure affects eyes, skin, respiratory system; repeated high-level exposure aggravates irritation
Other Health Effects: No specific effect on liver, kidney, or blood identified in limited tests
Aquatic Toxicity: Material considered of low immediate environmental hazard; high concentrations harm aquatic organisms
Persistence and Degradability: Not persistent, breaks down in aqueous environments
Bioaccumulative Potential: Strong water solubility and low partition coefficient suggest low bioaccumulation
Mobility in Soil: High mobility; runoff risk in large release events
Other Effects: Local contamination possible; avoid dumping into waterways or in bulk quantity on soil
Disposal Methods: Collect in suitable containers and dispose of via licensed chemical waste contractor; avoid landfill or sewage disposal
Containers: Decontaminate empty containers with water; dispose of rinsate via hazardous waste route
Special Precautions: Do not flush with copious water into environments; incinerate under controlled, permitted conditions if necessary
Regulation Reference: Comply with regional, national, and local resource conservation or hazardous waste regulations
UN Number: Not classified under any specific UN code
Transport Hazard Class: Not regulated as dangerous in transport under ADR, RID, IMDG, IATA
Packing Group: Not assigned
Environmental Hazards: Not considered marine pollutant
Special Precautions: Avoid rough handling; keep dry in transit; use sealed packaging
Shipping Information: Vehicles and carriers carry appropriate spill kit and PPE for accidental exposures
Emergency Response Guide: Reference local and international guidelines for hazardous chemical shipments
EU Regulations: Not listed in Annex VI of Regulation (EC) No 1272/2008 (CLP)
US Regulations: Listed for laboratory and research use; not included in major hazardous air or water pollutant lists from EPA
International Inventories: Components may appear on country inventories; check local chemical registration requirements
Labeling: Includes hazard pictograms (GHS07), signal word “Warning,” and phrase codes for hazard and precautionary statements
Occupational Safety: Employers inform staff and provide training on chemical hazards and accident procedures
Restrictions: Not controlled under specific chemical weapons, food, or drug legislation
