Product Name: Tetraphenylphosphonium Bromide
Chemical Formula: C24H20BrP
Synonyms: Tetraphenylphosphonium bromide, TPPB
CAS Number: 2751-90-8
Recommended Use: Laboratory reagent, phase transfer catalyst, research chemical
Manufacturer: Contact supplier for manufacturer information
Emergency Phone: Refer to supplier’s emergency contact
Relevant Identified Uses: Synthesis, laboratory procedures involving ionic transfers, organic chemistry studies
Classification: Harmful if swallowed, skin or eye irritant, acute toxicity (oral, category 4), skin irritation (category 2), eye irritation (category 2A)
Label Elements: Warning symbol (exclamation mark), hazard statement (“Harmful if swallowed or in contact with skin. Causes skin irritation. Causes serious eye irritation.”)
Precautionary Statements: Avoid breathing dust. Wash thoroughly after handling. Wear protective gloves, eye protection, and clothing.
Potential Health Effects: Inhalation or ingestion can lead to gastrointestinal discomfort. Skin contact may cause redness, itching, or irritation. Eye contact can result in redness, pain, or blurred vision. Prolonged exposure increases risk of toxic symptoms.
Target Organs: Mucous membranes, skin, eyes, digestive system.
Signal Word: Warning
Chemical Name: Tetraphenylphosphonium bromide
CAS Number: 2751-90-8
Concentration: >98% (pure reagent)
Impurities: No significant impurities expected in reagent-grade material
Molecular Weight: 419.30 g/mol
General Guidelines: Remove from exposure area, seek medical attention if symptoms develop. Ensure personal safety before assisting.
Inhalation: Move affected person to fresh air. If breathing feels difficult, provide oxygen or artificial respiration. Seek medical help.
Skin Contact: Wash area thoroughly with soap and water for at least 15 minutes. Remove contaminated clothing. Consult a physician if irritation appears or persists.
Eye Contact: Rinse opened eye with plenty of water for at least 15 minutes. Hold eyelids open throughout flushing. Obtain medical attention.
Ingestion: Rinse mouth with water (only if person is conscious). Do not induce vomiting. Seek immediate medical care.
Notes to Physician: Treat symptomatically and observe for allergic reactions or complications.
Suitable Extinguishing Media: Use dry chemical, CO2, water spray, or foam. Carbon dioxide works well for small fires.
Unsuitable Extinguishing Media: Direct water jet for larger quantities can spread material.
Fire Hazards: Combustible solid; toxic and irritating fumes (carbon oxides, phosphorus oxides, hydrogen bromide) may form.
Protective Equipment: Firefighters wear self-contained breathing apparatus; full protective clothing recommended.
Special Procedures: Approach windward to avoid hazardous vapors. Cool containers with water spray to prevent overheating.
Explosion Risks: No explosive properties known, standard fire behavior precautions apply.
Personal Precautions: Avoid dust formation and inhalation. Wear gloves, goggles, lab coat, and dust mask.
Environmental Precautions: Prevent further leakage or spillage if safe. Avoid runoff to drains, surface water, and soil.
Cleanup Methods: Sweep up and place in suitable container for disposal. Use tools that don’t generate dust. Wash spill site with detergent and water after material removal.
Decontamination: Ventilate area well during and after cleanup.
Disposal: Dispose in accordance with local, state, and federal regulations.
Handling: Use in well-ventilated area. Wear recommended personal protective equipment. Prevent dust cloud formation. Wash thoroughly after handling.
Storage: Store in tightly closed containers, in a dry, cool, and well-ventilated location. Keep away from sources of ignition and incompatible materials (oxidizing agents, strong acids).
Storage Temperature: Ambient temperature; avoid freezing or excessive heat.
Incompatible Materials: Strong oxidizers, strong acids, strong bases.
Special Instructions: Label containers clearly. Limit access to authorized personnel.
Occupational Exposure Limit: No specific exposure limits listed; practice general safe chemical handling.
Eye Protection: Chemical safety goggles or full-face shield.
Skin Protection: Gloves resistant to chemicals and long-sleeved lab coat.
Respiratory Protection: Use NIOSH-approved dust respirator if dust or aerosol is present.
Engineering Controls: Local exhaust ventilation, good general room ventilation.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Do not eat, drink, or smoke in work area.
Appearance: White to off-white crystalline solid or powder
Odor: No significant odor
Odor Threshold: Not determined
pH: Not applicable (non-aqueous solid)
Melting Point: About 276 – 283 °C
Boiling Point: Not available (decomposes on melting)
Flash Point: Not relevant
Evaporation Rate: Not applicable
Flammability: Not highly flammable; avoid open flames
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: Approximately 1.36 g/cm3
Solubility in Water: Slightly soluble
Solubility in Other Solvents: Moderately soluble in organic solvents (acetonitrile, ethanol)
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: About 280 °C
Viscosity: Not applicable (solid)
Chemical Stability: Chemically stable under ordinary conditions of use and storage.
Hazardous Reactions: Reacts with strong oxidizing agents, strong acids, and bases.
Conditions to Avoid: Moisture, elevated temperatures, dust formation.
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, phosphorus oxides.
Polymerization: Will not polymerize.
Reactive Incompatibility: Avoid contact with reactive metals and strong oxidizers.
Potential Acute Effects: Harmful if inhaled, ingested, or upon skin contact. May cause irritation of eyes, skin, and respiratory tract.
Chronic Effects: Long-term exposure not well studied; general recommendation to minimize repeated or prolonged contact.
LD50 (Oral, Rat): Data not well documented; chemical structure suggests moderate toxicity.
LD50 (Dermal, Rabbit): Not established.
Skin Irritation: May result in redness and itching.
Eye Irritation: Causes moderate to severe irritation, possible eye damage with direct, prolonged exposure.
Respiratory Sensitization: Not established
Carcinogenicity: No evidence for carcinogenic potential in available literature.
Mutagenicity: Data unavailable
Reproductive Toxicity: No evidence or studies indicating reproductive risks.
Aquatic Toxicity: No specific data measured. Avoid release to environment due to chemical composition.
Persistence/Degradability: Not readily biodegradable; possible long-term effects in aquatic settings.
Bioaccumulation Potential: Not sufficiently studied; based on structure, low to moderate risk.
Mobility in Soil: Limited mobility; binds to soil solids
Other Adverse Effects: Expected to impact aquatic organisms if large quantities reach waterways.
Prevention of Release: Prevent entry into drains and waterways; take precautions during handling and disposal.
Waste Disposal Methods: Send to licensed chemical disposal contractor. Small quantities may be mixed with combustible material and incinerated in a chemical incinerator equipped with afterburner and scrubber.
Container Disposal: Rinse thoroughly and dispose of in accordance with local requirements.
Sewage Disposal: Do not discharge to municipal sewage systems or surface water.
Contaminated Packaging: Treat as hazardous chemical waste.
Regulatory Disposal Requirements: Follow EPA, state, and local regulations.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as a hazardous material for air, sea, or road transport
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Avoid transport with food and feedstuffs. Minimize risk of spills.
Special Precautions for User: Store and transport in well-sealed containers. Protect from physical damage and moisture during transit.
TSCA Status: Listed
DSL/NDSL (Canada): Listed
REACH Status (EU): Not registered
OSHA Hazards: Irritant; hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200)
SARA Title III Section 313: Not subject
California Proposition 65: Not listed
WHMIS (Canada): D2B – Toxic material causing other toxic effects
Labeling Requirements: Safety labeling per local regulatory guidance.
Further Requirements: Check country-specific chemical inventories. Maintain safety data sheet accessibility for users.
