Product Name: Tri-N-Butylphosphine Oxide
Synonyms: Tributylphosphine oxide
CAS Number: 1070-08-4
Molecular Formula: C12H27OP
Molecular Weight: 218.32 g/mol
Recommended Use: Laboratory chemical, industrial applications, ligand in organic synthesis
Supplier Name: Refer to packaging or purchasing department for manufacturer details and emergency contact information
GHS Classification: Skin irritation: Category 2; Eye irritation: Category 2A; Specific target organ toxicity (single exposure): Category 3
Hazard Statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory tract irritation.
Pictograms: Exclamation mark (GHS07)
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, fumes, or vapors. Wash affected skin thoroughly after handling. Use only outdoors or in well-ventilated areas. Wear protective gloves, protective clothing, eye protection, face protection.
Chemical Name: Tri-N-Butylphosphine Oxide
Common Name: TBPO
Concentration: ≥ 98% (commercial grades)
CAS Number: 1070-08-4
Impurities: Trace phosphine oxide derivatives possible depending on manufacturing route
Additives: None reported
EC Number: 213-972-3
General Advice: Remove contaminated clothing and shoes promptly, ensure open access to fresh air. Monitor vital signs if needed.
Inhalation: Move individual to fresh air, keep comfortable for breathing. If symptoms persist, seek medical attention immediately.
Skin Contact: Rinse area thoroughly with plenty of water and soap. Remove contaminated clothing. Consult a physician for prolonged irritation.
Eye Contact: Rinse cautiously for several minutes under running water. Remove contact lenses if present and easy to do. Continue rinsing. Seek immediate medical assistance if irritation continues.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Seek medical advice if feeling unwell or if large amount is swallowed.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide. Avoid high-pressure water streams that may spread the substance.
Fire Hazards: Product does not burn easily but may decompose under intense heat to generate hazardous phosphorus oxides and carbon oxides.
Protective Equipment: Wear self-contained breathing apparatus, full protective gear, and chemical-resistant gloves.
Special Procedures: Isolate area and deny entry to unnecessary personnel; use water spray to cool containers exposed to flames.
Hazardous Combustion Products: Phosphorus oxides (POx), carbon monoxide (CO), carbon dioxide (CO2)
Personal Precautions: Use proper personal protective equipment (PPE): gloves, goggles, and suitable respirator if dust or vapors become significant.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Prevent entry to sewers, surface water, and soil.
Methods for Cleanup: Absorb spill with inert material (sand, earth, vermiculite), collect and place in suitable container for disposal. Ventilate area, wash affected surfaces with soap and water after removal.
Decontamination: Wash area with copious amounts of water. Dispose of cleaning materials according to local, regional, and national guidelines.
Emergency Procedures: Evacuate non-essential personnel, stop source of spill, alert emergency response team if larger spill occurs.
Handling: Avoid contact with skin, eyes, and clothing. Do not breathe dust, fumes, or vapors. Use only in well-ventilated areas. Wash hands thoroughly after handling. Prevent formation of aerosols.
Storage: Store tightly closed in a cool, dry, well-ventilated area. Keep away from incompatible substances such as strong oxidizers and acids. Keep container upright and sealed to avoid moisture uptake. Segregate from food and feed.
Recommended Containers: Use approved chemical containers and ensure labeling is intact. Avoid plastic containers that may react with phosphine derivatives.
Exposure Limits: No specific OSHA or ACGIH exposure limits established for Tri-N-Butylphosphine Oxide. Apply general chemical hygiene principles.
Engineering Controls: Employ fume extraction, local exhaust ventilation, or work inside chemical fume hoods when possible.
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, lab coat or apron. Use appropriate respiratory protection if exposure risk increases due to dust, vapor, or aerosol.
Environmental Controls: Avoid discharge into the environment. Ensure effective containment methods for waste and accidental releases. Monitor workplace exposure through regular air sampling where large quantities are handled.
Appearance: Colorless to pale yellow liquid or crystalline solid, may darken slightly on exposure to air
Odor: Slight, characteristic, faint organic odor
Melting Point: 59-61°C (138-142°F)
Boiling Point: 327°C (620°F) at 760 mm Hg
Flash Point: 138°C (280°F)
Evaporation Rate: Slow, non-volatile under ambient conditions
Flammability: Not considered highly flammable, may combust with strong ignition source
Vapor Pressure: <0.01 mm Hg at 25°C
Density: 0.97 g/mL at 25°C
Solubility: Practically insoluble in water, soluble in many organic solvents (alcohol, ether)
pH: Not applicable
Partition Coefficient (log Kow): Estimated 4.0-5.0 (hydrophobic character)
Viscosity: Not readily available
Decomposition Temperature: Above 200°C may generate hazardous gases
Chemical Stability: Stable under recommended storage conditions, no significant hazard under routine handling
Reactivity: May react with strong oxidizing agents and strong acids to release hazardous products
Conditions to Avoid: Heat, sparks, open flames, moisture, exposure to air for extended periods
Incompatible Materials: Acids, oxidizing agents, alkaline compounds
Hazardous Decomposition Products: May generate toxic fumes of phosphorus oxides and carbon oxides if burned or decomposed
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 (rat) >2000 mg/kg, considered low acute toxicity for mammals
Skin Corrosion/Irritation: Causes skin irritation, may result in redness, itching, or swelling
Serious Eye Damage/Irritation: Causes serious eye irritation, tearing, and conjunctivitis possible
Respiratory Effects: May cause irritation of the respiratory tract upon inhalation of dust, vapor, or mist
Chronic Effects: Long-term exposure data limited, but prolonged or repeated skin contact may cause dermatitis
Carcinogenicity: Not identified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity and Reproductive Toxicity: No reliable mutagenic or reproductive toxicity data reported
Sensitization: Not expected to be a sensitizer based on available studies
Toxicity to Aquatic Life: Limited data available, but potential toxicity to fish and aquatic invertebrates can’t be ruled out due to hydrophobic nature
Persistence and Degradability: Low solubility and hydrophobicity suggest slow degradation in aquatic environments; may accumulate in sediments
Bioaccumulation Potential: Estimated high based on log Kow; may accumulate in aquatic organisms
Mobility in Soil: Low mobility predicted; likely to adsorb to soil particles
Other Adverse Effects: Environmental release must be avoided; best practice to minimize exposure to ecosystems and use closed systems for handling
Waste Treatment Methods: Dispose of in accordance with federal, state, and local environmental control regulations. Incineration in a chemical incinerator equipped with afterburner and scrubber is preferred.
Unused Product: Return to supplier or send to licensed hazardous waste disposal contractor.
Contaminated Packaging: Treat as hazardous; thoroughly clean or puncture prior to disposal. Follow all label instructions regarding packaging and labeling.
Special Precautions: Avoid release to the environment. Prevent from entering drains, soils, or watercourses.
UN Number: Not classified as dangerous goods for transport by most regulatory bodies
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Proper Shipping Name: Tri-N-Butylphosphine Oxide
Marine Pollutant: Not specifically listed, but avoid large-scale release
Special Precautions for Transport: Keep containers tightly sealed, protect from physical damage, and secure loads during transit
OSHA Status: Chemical is not specifically regulated, but general chemical hygiene and hazard communication rules apply
TSCA Inventory: Listed
EU REACH Status: Registered or pre-registered for REACH compliance in commercial quantities
DSL/NDSL (Canada): Listed or deemed acceptable for research use
SARA Title III (Sections 311/312): Acute health hazard
Other Regulations: All national and local safety, handling, and disposal guidelines apply. Compliance with chemical storage and waste laws in your jurisdiction essential for safe and lawful use.
